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上海药物研究所 [9]
山东大学 [6]
西安交通大学 [4]
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期刊论文 [41]
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2018 [41]
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Identification of a cellularly active SIRT6 allosteric activator
期刊论文
NATURE CHEMICAL BIOLOGY, 2018, 卷号: 14, 期号: 12, 页码: 1118-+
作者:
Huang, Zhimin
;
Zhao, Junxing
;
Deng, Wei
;
Chen, Yingyi
;
Shang, Jialin
收藏
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浏览/下载:95/0
  |  
提交时间:2019/01/08
Pharmacological characterization of hetrombopag, a novel orally active human thrombopoietin receptor agonist
期刊论文
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2018, 卷号: 22, 期号: 11, 页码: 5367-5377
作者:
Xie, Chengying
;
Zhao, Huajun
;
Bao, Xubin
;
Fu, Haoyu
;
Lou, Liguang
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
eltrombopag
hetrombopag
hollow-fibre assay
thrombopoietin
thrombopoietin receptor
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916
作者:
Wang, Beilei
;
Wu, Jiaxin
;
Wu, Yun
;
Chen, Cheng
;
Zou, Fengming
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  |  
浏览/下载:70/0
  |  
提交时间:2019/12/25
CDK9
Kinase inhibitor
Structure-activity relationship
Leukemia
Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase‑dependent pathway
期刊论文
Oncology reports, 2018, 卷号: 40, 期号: 4, 页码: 1985-1993
作者:
Dong, Xiaoxv
;
Ni, Boran
;
Fu, Jing
;
Yin, Xingbin
;
You, Longtai
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  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
DCZ3301, a novel aryl-guanidino inhibitor, induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 卷号: 50, 期号: 7, 页码: 643-650
作者:
Xiao, Wenqin
;
Li, Bo
;
Sun, Xi
;
Yu, Dandan
;
Xie, Yongsheng
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2019/01/08
DCZ3301
T-cell leukemia/lymphoma
apoptosis
cell cycle
PI3K/AKT
Design, synthesis, and molecular docking study of 3H-imidazole[4,5-c]pyridine derivatives as CDK2 inhibitors
期刊论文
ARCHIV DER PHARMAZIE, 2018, 卷号: 351, 期号: 6
作者:
Wu, Yi-Zhe
;
Ying, Hua-Zhou
;
Xu, Lei
;
Cheng, Gang
;
Chen, Jing
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/01/08
cancer
CDK2 inhibitor
imidazo[4
5-c]pyridine
targeted therapy
The cyclin-dependent kinase 2 (CDK2) mediates hematopoiesis through G1-to-S transition in Chinese mitten crab Eriocheir sinensis
期刊论文
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2018, 卷号: 81, 页码: 156-166
作者:
Yang, Bin
;
Jia, Yunke
;
Jia, Zhihao
;
Wang, Weilin
;
Song, Xiaorui
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  |  
浏览/下载:27/0
  |  
提交时间:2019/08/21
Eriocheir sinensis
Innate immunity
CDK2
Cell cycle
Hematopoiesis
Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor
期刊论文
MOLECULAR NUTRITION & FOOD RESEARCH, 2018, 卷号: 62, 期号: 7
作者:
Liu, Rongxia
;
Heiss, Elke H.
;
Waltenberger, Birgit
;
Blazevic, Tina
;
Schachner, Daniel
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
Mediterranean spices
neointima formation
rosmarinic acid
rosmarinic acid methyl ester
vascular smooth muscle cells
Lipid-Based Liquid Crystalline Nanoparticles Facilitate Cytosolic Delivery of siRNA via Structural Transformation
期刊论文
NANO LETTERS, 2018, 卷号: 18, 期号: 4, 页码: 2411-2419
作者:
He, Shufang
;
Fan, Weiwei
;
Wu, Na
;
Zhu, Jingjing
;
Miao, Yunqiu
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
Lipids
liquid crystalline nanoparticles
siRNA delivery
endosomal escape
synthetic lethality
A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway
期刊论文
MARINE DRUGS, 2018, 卷号: 16, 期号: 2, 页码: 13
作者:
Guo, Chuan-Long
;
Wang, Li-Jun
;
Zhao, Yue
;
Liu, Hua
;
Li, Xiang-Qian
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/08/21
bromophenol
molecular mechanisms
apoptosis
cell cycle
PI3K
Akt
p38
ERK
ROS
human lung cancer
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