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科研机构
西北高原生物研究所 [9]
上海药物研究所 [8]
湖南大学 [5]
昆明植物研究所 [2]
复旦大学上海医学院 [2]
中国医学科学院 北京... [2]
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期刊论文 [40]
发表日期
2018 [40]
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Engineerin... [1]
Materials ... [1]
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发表日期:2018
内容类型:期刊论文
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Pyrazolo[4,3-b]pyrimido[4,5-e][1,4]diazepine derivatives as new multi-targeted inhibitors of Aurora A/B and KDR
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 428-441
作者:
Zhang, Qiumeng
;
Shen, Qianqian
;
Gao, Lixin
;
Tong, Linjiang
;
Li, Jia
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
Aurora A
Aurora B
KDR
Multi-targeted
Anticancer
Heterocyclic
Synthesis, biological evaluation and structure-activity relationship of a novel class of PI3K alpha H1047R mutant inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 707-719
作者:
Zhang, Ning
;
Yu, Zhimei
;
Yang, Xiaohong
;
Zhou, Yan
;
Wang, Jia
收藏
  |  
浏览/下载:89/0
  |  
提交时间:2019/01/08
Anticancer drug
Phosphatidylinositol 3-kinase
Structure-activity relationship
Synthesis and In Vitro Antitumor Activity of Novel Bivalent -Carboline-3-carboxylic Acid Derivatives with DNA as a Potential Target
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 卷号: 19, 期号: 10
作者:
Gu, Hongling
;
Li, Na
;
Dai, Jiangkun
;
Xi, Yaxi
;
Wang, Shijun
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  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
bivalent -carbolines
antitumor
apoptosis
DNA-binding affinity
bcl-2
Emodin induces apoptosis in human hepatocellular carcinoma HepaRG cells via the mitochondrial caspase‑dependent pathway
期刊论文
Oncology reports, 2018, 卷号: 40, 期号: 4, 页码: 1985-1993
作者:
Dong, Xiaoxv
;
Ni, Boran
;
Fu, Jing
;
Yin, Xingbin
;
You, Longtai
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Discovery of novel wee1 inhibitors via structure-based virtual screening and biological evaluation
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2018, 卷号: 32, 期号: 9, 页码: 901-915
作者:
Li, Yaping
;
Pu, Yinglan
;
Liu, Hui
;
Zhang, Li
;
Liu, Xingyong
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2018/11/06
Wee1 inhibitors
Pharmacophore model
Molecular docking
Virtual screening
Molecular dynamics simulation
Polyfluorinated iodine alkanes regulated distinct breast cancer cell progression through binding with estrogen receptor alpha or beta isoforms
期刊论文
ENVIRONMENTAL POLLUTION, 2018, 卷号: 239, 页码: 300-307
作者:
Zhou, Qunfang
;
Song, Wenting
;
Liu, Qian S.
;
Sun, Zhendong
;
Yang, Xiaoxi
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/06/20
Polyfluorinated iodine alkanes
Estrogen receptor isoforms
Breast cancer cells
Cell proliferation
Cell cycle distribution
New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2018, 卷号: 154, 页码: 255-264
作者:
Tian, Qian-Ting
;
Ding, Chun-Yong
;
Song, Shan-Shan
;
Wang, Ying-Qing
;
Zhang, Ao
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  |  
浏览/下载:42/0
  |  
提交时间:2019/01/08
Tanshinone-1
S222
S439
Anticancer targets
DNA topoisomerases
P53
DCZ3301, a novel aryl-guanidino inhibitor, induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma
期刊论文
ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 卷号: 50, 期号: 7, 页码: 643-650
作者:
Xiao, Wenqin
;
Li, Bo
;
Sun, Xi
;
Yu, Dandan
;
Xie, Yongsheng
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2019/01/08
DCZ3301
T-cell leukemia/lymphoma
apoptosis
cell cycle
PI3K/AKT
Cell Cycle Arrest and Apoptosis in HT-29 Cells Induced by Dichloromethane Fraction From Toddalia asiatica (L.) Lam.
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9, 页码: 11
作者:
Jin, Qinghao
;
Guo, Mingquan
;
Li, Xun
;
Qiu, Zidong
;
Chen, Guilin
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2018/12/29
colon cancer
Toddalia asiatica Lam.
G2/M arrest
apoptosis
reactive oxygen species
Cell Cycle Arrest and Apoptosis in HT-29 Cells Induced by Dichloromethane Fraction From Toddalia asiatica (L.) Lam.
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Li, Xun
;
Qiu, Zidong
;
Jin, Qinghao
;
Chen, Guilin
;
Guo, Mingquan
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
colon cancer
Toddalia asiatica Lam.
G2/M arrest
apoptosis
reactive oxygen species
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