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科研机构
上海药物研究所 [33]
高能物理研究所 [19]
合肥物质科学研究院 [12]
湖南大学 [6]
厦门大学 [5]
复旦大学上海医学院 [5]
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内容类型
期刊论文 [135]
学位论文 [5]
会议论文 [1]
发表日期
2017 [141]
学科主题
Oncology [1]
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Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61
作者:
Li, Xin
;
Yang, Changyong
;
Wan, Hong
;
Zhang, Ge
;
Feng, Jun
收藏
  |  
浏览/下载:137/0
  |  
提交时间:2019/01/08
Pyrotinib
HER2-postive breast cancer
Irreversible EGFR/HER2 dual tyrosine kinase
inhibitor
Preclinical
Clinical
Safety
Drug metabolism
Serum Metabolic Profile Alteration Reveals Response to Platinum-Based Combination Chemotherapy for Lung Cancer: Sensitive Patients Distinguished from Insensitive ones
期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:
Xu, Shan
;
Zhou, Yanping
;
Geng, Hui
;
Song, Dandan
;
Tang, Jing
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2018/11/05
Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 64, 页码: 107977-107990
作者:
Xie, Chengying
;
Chen, Xiangling
;
Zheng, Mingyue
;
Liu, Xiaohong
;
Wang, Hongbin
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
BEZ235
drug resistance
mTOR
PI3K
SHR8443
Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 12, 页码: 1642-1654
作者:
Li, Jing-qiu
;
Wu, Xian
;
Gan, Lu
;
Yang, Xiang-liang
;
Miao, Ze-hong
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
hepatocellular carcinoma
hypoxia
5-fluorouracil
sorafenib
drug resistance
Reprogramming Tumor-Associated Macrophages To Reverse EGFR(T790M) Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat
期刊论文
NANO LETTERS, 2017, 卷号: 17, 期号: 12, 页码: 7684-7690
作者:
Peng, Huige
;
Chen, Binfan
;
Huang, Wei
;
Tang, Yubo
;
Jiang, Yifan
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2019/01/08
Tumor-associated macrophages
gefitinib
vorinostat
EGFR(T790M)
nonsmall cell lung cancer
drug resistance
Dual-Targeting to Cancer Cells and M2 Macrophages via Biomimetic Delivery of Mannosylated Albumin Nanoparticles for Drug-Resistant Cancer Therapy
期刊论文
ADVANCED FUNCTIONAL MATERIALS, 2017, 卷号: 27, 期号: 44
作者:
Zhao, Pengfei
;
Yin, Weimin
;
Wu, Aihua
;
Tang, Yisi
;
Wang, Jinyu
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
albumin nanoparticles
combination therapy
mannose receptors
multidrug resistance
SPARC
Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 510-527
作者:
Chen, Lingfeng
;
Fu, Weitao
;
Feng, Chen
;
Qu, Rong
;
Tong, Linjiang
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
Epidermal growth factor receptor
Tyrosine kinase inhibitors
Non-small cell lung cancer
T790M
Mutant-selective
Overcoming resistance to cisplatin by inhibition of glutathione s-transferases (gsts) with ethacraplatin micelles in vitro and in vivo
期刊论文
Biomaterials, 2017, 卷号: 144, 页码: 119-129
作者:
Li, Shuyi
;
Li, Chan
;
Jin, Shubin
;
Liu, Juan
;
Xue, Xiangdong
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/04/23
Cisplatin resistance
Glutathione s-transferases (gsts)
Ethacraplatin
Drug delivery
Co-delivery of itraconazole and docetaxel by core/shell lipid nanocells for systemic antiangiogenesis and tumor growth inhibition
期刊论文
Journal of biomedical nanotechnology, 2017, 卷号: 13, 期号: 11, 页码: 1398-1412
作者:
Okeke, Chukwunweike I.
;
Eltahan, Ahmed S.
;
Zhang, Tingbin
;
Chen, Jing
;
Wang, Yingze
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/04/23
Antiangiogenesis
Itraconazole
Docetaxel
Core/shell nanocarrier
Combinational therapy
Albumin Binding Domain Fusing R/K-X-X-R/K Sequence for Enhancing Tumor Delivery of Doxorubicin
期刊论文
MOLECULAR PHARMACEUTICS, 2017, 卷号: 14, 期号: 11, 页码: 3739-3749
作者:
Liu, Liping
;
Zhang, Chun
;
Li, Zenglan
;
Wang, Chunyue
;
Bi, Jingxiu
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2017/12/20
Albumin Binding Domain
Rgdk
Rparpar
Doxorubicin
Peptide-drug Conjugate
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