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浏览/检索结果: 共33条，第1-10条 帮助 限定条件 发表日期：2017    内容类型：期刊论文    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer 期刊论文 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61 作者:  Li, Xin;  Yang, Changyong;  Wan, Hong;  Zhang, Ge;  Feng, Jun 收藏  |  浏览/下载：138/0  |  提交时间：2019/01/08 Pyrotinib  HER2-postive breast cancer  Irreversible EGFR/HER2 dual tyrosine kinase  inhibitor  Preclinical  Clinical  Safety  Drug metabolism   Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin 期刊论文 ONCOTARGET, 2017, 卷号: 8, 期号: 64, 页码: 107977-107990 作者:  Xie, Chengying;  Chen, Xiangling;  Zheng, Mingyue;  Liu, Xiaohong;  Wang, Hongbin 收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 BEZ235  drug resistance  mTOR  PI3K  SHR8443   Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 12, 页码: 1642-1654 作者:  Li, Jing-qiu;  Wu, Xian;  Gan, Lu;  Yang, Xiang-liang;  Miao, Ze-hong 收藏  |  浏览/下载：32/0  |  提交时间：2019/01/08 hepatocellular carcinoma  hypoxia  5-fluorouracil  sorafenib  drug resistance   Reprogramming Tumor-Associated Macrophages To Reverse EGFR(T790M) Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat 期刊论文 NANO LETTERS, 2017, 卷号: 17, 期号: 12, 页码: 7684-7690 作者:  Peng, Huige;  Chen, Binfan;  Huang, Wei;  Tang, Yubo;  Jiang, Yifan 收藏  |  浏览/下载：66/0  |  提交时间：2019/01/08 Tumor-associated macrophages  gefitinib  vorinostat  EGFR(T790M)  nonsmall cell lung cancer  drug resistance   Dual-Targeting to Cancer Cells and M2 Macrophages via Biomimetic Delivery of Mannosylated Albumin Nanoparticles for Drug-Resistant Cancer Therapy 期刊论文 ADVANCED FUNCTIONAL MATERIALS, 2017, 卷号: 27, 期号: 44 作者:  Zhao, Pengfei;  Yin, Weimin;  Wu, Aihua;  Tang, Yisi;  Wang, Jinyu 收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08 albumin nanoparticles  combination therapy  mannose receptors  multidrug resistance  SPARC   Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 140, 页码: 510-527 作者:  Chen, Lingfeng;  Fu, Weitao;  Feng, Chen;  Qu, Rong;  Tong, Linjiang 收藏  |  浏览/下载：57/0  |  提交时间：2019/01/08 Epidermal growth factor receptor  Tyrosine kinase inhibitors  Non-small cell lung cancer  T790M  Mutant-selective   Discovery of Novel Macrocyclic Hedgehog Pathway Inhibitors Acting by Suppressing the Gli-Mediated Transcription 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 19, 页码: 8218-8245 作者:  Liu, Gang;  Huang, Wenjing;  Wang, Juan;  Liu, Xiaohua;  Yang, Jun 收藏  |  浏览/下载：13/0  |  提交时间：2019/01/08 Acidity-Triggered Ligand-Presenting Nanoparticles To Overcome Sequential Drug Delivery Barriers to Tumors 期刊论文 NANO LETTERS, 2017, 卷号: 17, 期号: 9, 页码: 5429-5436 作者:  Wang, Tingting;  Wang, Dangge;  Liu, Jianping;  Feng, Bing;  Zhou, Fangyuan 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 Drug delivery barriers  acid-responsive  ligand presentation  tumor microenvironment  cancer therapy   Selective targeting p53(WT) lung cancer cells harboring homozygous p53 Arg72 by an inhibitor of CypA 期刊论文 ONCOGENE, 2017, 卷号: 36, 期号: 33, 页码: 4719-4731 作者:  Lu, W.;  Cheng, F.;  Yan, W.;  Li, X.;  Yao, X. 收藏  |  浏览/下载：8/0  |  提交时间：2019/01/08 Co-Delivery of Trichosanthin and Albendazole by Nano-Self Assembly for Overcoming Tumor Multidrug-Resistance and Metastasis 期刊论文 ACS APPLIED MATERIALS & INTERFACES, 2017, 卷号: 9, 期号: 32, 页码: 26648-26664 作者:  Tang, Yisi;  Liang, Jianming;  Wu, Aihua;  Chen, Yingzhi;  Zhao, Pengfei 收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08 Multidrug resistance  trichosanthin  albendazole  albumin nanoparticles  silver nanoparticles  metastasis