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An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 21, 页码: 9575-9598
作者:  Wang, Ying-Qing;  Wang, Ping-Yuan;  Wang, Yu-Ting;  Yang, Guang-Fu;  Zhang, Ao
收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08
Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer 期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 41, 页码: 67071-67086
作者:  Qian, Jianchang;  Chen, Yaqing;  Meng, Tao;  Ma, Lanping;  Meng, Lanfang
收藏  |  浏览/下载：35/0  |  提交时间：2019/01/08
Synergistic Therapy of Doxorubicin and miR-129-5p with Self-Cross-Linked Bioreducible Polypeptide Nanoparticles Reverses Multidrug Resistance in Cancer Cells 期刊论文
BIOMACROMOLECULES, 2016
作者:  Yi, Huqiang;  Liu, Lanlan;  Sheng, Nan;  Li, Ping;  Pan, Hong
收藏  |  浏览/下载：22/0  |  提交时间：2017/01/16
Down-Regulation of the Cyclin-Dependent Kinase Inhibitor p57 Is Mediated by Jab1/Csn5 in Hepatocarcinogenesis 期刊论文
HEPATOLOGY, 2016, 卷号: 63, 期号: [db:dc_citation_issue], 页码: 898-913
作者:  Guo, Hui;  Jing, Li;  Cheng, Yangzi;  Atsaves, Vassilis;  Lv, Yi
收藏  |  浏览/下载：9/0  |  提交时间：2019/12/02
A Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma Cells 期刊论文
PLOS ONE, 2016
Cao, Lili; Zhang, Lijun; Zhao, Xiang; Zhang, Ye
收藏  |  浏览/下载：14/0  |  提交时间：2017/12/04
Identification of YPL014W (Cip1) as a novel negative regulator of cyclin-dependent kinase in Saccharomyces cerevisiae 期刊论文
GENES TO CELLS, 2016
Ren, Ping; Malik, Asrar; Zeng, Fanli
收藏  |  浏览/下载：4/0  |  提交时间：2017/12/04
The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect 期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 162, 页码: 179-187
作者:  Chu, Shifeng;  Liu, Shaolin;  Duan, Wenzhen;  Cheng, Yong;  Jiang, Xueying
收藏  |  浏览/下载：9/0  |  提交时间：2019/12/27
Chirality  Clausenamide  Dementia  Long-term potentiation  Signaling pathway  Calcium  6-OHDA  6-hydroxyldopamine  ACE  acetylcholinesterase  ACh  acetylcholine  AD  Alzheimer's disease  AUC0–12 h  0–12 h area under curve  APP  amyloid precursor protein  APV  R-2-amino-5-phosphonopentanoate  AUC0−∝  whole area under curve  BBB  blood–brain barrier  BDNF  brain-derived neurotrophic factor  CaM  calmodulin  CaMKII  calmodulin kinase II  ChAT  choline acetyltransferase  CREB  cAMP responding element binding  CHM  Chinese herbal medicine  clau  clausenamide  CL  clearance  Cmax  maximum concentration  CDK-5  cyclin-dependent kinase-5  DM  diabetes mellitus  DAG  diacylglycerol  ER  endoplasmic reticulum  ERK  extracellular signal-regulated kinases  GSK-3  glycogen synthase kinase-3  IP3  inositol triphosphate  LTP  long term potentiation  MWM  Morris water maze  NGF  nerve growth factor  NMDA  N-Methyl-D-aspartate  D  nNOS  neural nitric oxide synthase  PAT  passive avoidance tasks  Pir  piracetam  PLC  phospholipase C  PP1  phosphate 1  PKC  protein kinase C  tmax  time of peak concentration  t1/2α  absorption half-life  t1/2β  elimination half-life  Tau  microtubule-associated proteins  TCM  traditional Chinese medicine  Vd  apparent volume of distribution  VDCC  voltage-dependent calcium channel  
The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y 期刊论文
Gene, 2016, 卷号: 588, 期号: 1, 页码: 62-68
作者:  Ma, Yun*;  Tian, Shuai;  He, Shuya*;  Chen, Qiong;  Wang, Zongbao
收藏  |  浏览/下载：17/0  |  提交时间：2019/12/27
mRNA  messenger ribonucleic acid  miRNA  micro ribonucleic acid  TNF-α  tumor necrosis factor-alpha  SH-SY5Y  cells SH-SY5Y neuroblastoma cells  Ago2  Argonaute 2  USP32  ubiquitin specific peptidase 32  RAB18  member RAS oncogene family  Dusp6  dual specificity phosphatase 6  Cdkn1a  cyclin-dependent kinase inhibitor 1A  Bcl-2  B-cell lymphoma-2  FMRP  fragile X mental retardation protein  FXR1P  fragile X-related 1 protein  FXR2P  fragile X-related 2 protein  3′UTR  3′untranslated regions  CDS  coding sequence  FACS  fluorescence activated cell sorter  PMSF  phenylmethanesulfonyl fluoride  SDS-PAGE  sodium dodecyl sulfate-polyacrylamide gel electrophoresis  ANOVA  analysis of variance  SD  standard deviation  PCR  polymerase chain reaction  miR-19b  FXR1  RAB18  USP32  Dusp6  
The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y 期刊论文
Gene, 2016, 卷号: 588, 期号: 1, 页码: 62-68
作者:  Ma, Yun*;  Tian, Shuai;  He, Shuya*;  Chen, Qiong;  Wang, Zongbao
收藏  |  浏览/下载：19/0  |  提交时间：2019/12/27
mRNA  messenger ribonucleic acid  miRNA  micro ribonucleic acid  TNF-α  tumor necrosis factor-alpha  SH-SY5Y  cells SH-SY5Y neuroblastoma cells  Ago2  Argonaute 2  USP32  ubiquitin specific peptidase 32  RAB18  member RAS oncogene family  Dusp6  dual specificity phosphatase 6  Cdkn1a  cyclin-dependent kinase inhibitor 1A  Bcl-2  B-cell lymphoma-2  FMRP  fragile X mental retardation protein  FXR1P  fragile X-related 1 protein  FXR2P  fragile X-related 2 protein  3′UTR  3′untranslated regions  CDS  coding sequence  FACS  fluorescence activated cell sorter  PMSF  phenylmethanesulfonyl fluoride  SDS-PAGE  sodium dodecyl sulfate-polyacrylamide gel electrophoresis  ANOVA  analysis of variance  SD  standard deviation  PCR  polymerase chain reaction  miR-19b  FXR1  RAB18  USP32  Dusp6  
Chikusetsusaponin IVa methyl ester induces G1 cell cycle arrest, triggers apoptosis and inhibits migration and invasion in ovarian cancer cells 期刊论文
Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, 卷号: 23, 期号: 13, 页码: 1555-1565
作者:  Chen, Xin;  Wu, Qiu-Shuang;  Meng, Fan-Cheng
收藏  |  浏览/下载：10/0  |  提交时间：2019/12/27
Panacis Japonici Rhizoma  Chikusetsusaponin IVa methyl ester  Ovarian cancer  Cell cycle arrest  Apoptosis  Metastasis  Bcl-2  B-cell lymphoma 2  CC  column chromatography  CDK  cyclin-dependent kinase  DMEM  Dulbecco's modified Eagle's medium  DMSO  dimethyl sulfoxide  FBS  fetal bovine serum  GAPDH  Glyceraldehyde 3-phosphate dehydrogenase  Hoechst 33342  2′-[4-ethoxyphenyl]-5-[4-methyl-1-piperazinyl]-2,5′-bi-1H-benzimidazole trihydrochloride trihydrate  JC-1  5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimi-dazolylcarbocyanine iodide  MMP  matrix metalloproteinase  MTT  3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide  PARP  Poly (ADP-ribose) polymerase  PBS  phosphate-buffered saline  PI  ropidium iodide  PJR  Panacis Japonici Rhizoma  SD  standard deviation  

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