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浏览/检索结果: 共45条，第1-10条 帮助 限定条件 发表日期：2016    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Design, Synthesis, and Pharmacological Evaluation of 2-(2,5-Dimethyl-5,6,7,8-tetrahydroquinolin-8-yl)-N-aryl Propanamides as Novel Smoothened (Smo) Antagonists 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 24, 页码: 11050-11068 作者:  Liu, Gang;  Xue, Ding;  Yang, Jun;  Wan, Juan;  Liu, Xiaohua 收藏  |  浏览/下载：54/0  |  提交时间：2019/01/08 Preclinical Efficacy and Safety Assessment of Artemisinin-Chemotherapeutic Agent Conjugates for Ovarian Cancer 期刊论文 EBIOMEDICINE, 2016, 卷号: 14, 页码: 44-54 作者:  Li, Xiaoguang;  Zhou, Yu;  Liu, Yanling;  Zhang, Xu;  Chen, Tao 收藏  |  浏览/下载：31/0  |  提交时间：2019/01/08 Dihydroartemisinin  Drug conjugates  Cell cycle  Apoptosis  Metastasis  Ovarian cancer   Estimation of elimination half-lives of organic chemicals in humans using gradient boosting machine 期刊论文 BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2016, 卷号: 1860, 期号: 11, 页码: 2664-2671 作者:  Lu, Jing;  Lu, Dong;  Zhang, Xiaochen;  Bi, Yi;  Cheng, Keguang 收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08 Elimination half-life  Gradient boosting machine  Applicability domain  Consensus model   Design, Synthesis, and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives (THPBs) as Selective alpha(1A)-Adrenoceptor Antagonists 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 20, 页码: 9489-9502 作者:  Guo, Diliang;  Li, Jing;  Lin, Henry;  Zhou, Yu;  Chen, Ying 收藏  |  浏览/下载：30/0  |  提交时间：2019/01/08 Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry 期刊论文 JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2016, 卷号: 1033, 页码: 117-127 作者:  Zhu, Yunting;  Li, Liang;  Zhang, Ge;  Wan, Hong;  Yang, Changyong 收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08 Pyrotinib  UPLC/Q-TOF MS  Metabolism  Human  CYP3A4  Drug-drug interaction   Three dimensional structural insight of laser drilled orifices in osmotic pump tablets 期刊论文 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 卷号: 93, 页码: 287-294 作者:  Wu, Li;  Wang, Lebing;  Wang, Shuxia;  Xiao, Tiqiao;  Chen, Min 收藏  |  浏览/下载：25/0  |  提交时间：2019/01/08 Structure  Osmotic pump tablet  Synchrotron radiation X-ray microcomputed  tomography  Laser drilling   HER2-targeted antibody drug conjugates for ovarian cancer therapy 期刊论文 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 卷号: 93, 页码: 274-286 作者:  Jiang, Jing;  Dong, Lihou;  Wang, Lei;  Wang, Ling;  Zhang, Jing 收藏  |  浏览/下载：54/0  |  提交时间：2019/01/08 Ovarian cancer  Antibody drug conjugates (ADCs)  HER2/ErbB2  Monomethyl auristatin E (MMAE)   Design, Synthesis and Biological Evaluation of 6-(2,6-Dichloro-3,5-dimethoxyphenyl)-4-substituted-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors 期刊论文 MOLECULES, 2016, 卷号: 21, 期号: 10 作者:  Zhang, Zhen;  Zhao, Dongmei;  Dai, Yang;  Cheng, Maosheng;  Geng, Meiyu 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 cancer  FGFR  inhibitor  4-substituted-1H-indazole   Valuable model for clinical trail-System Toxicological Studies on Active Components in derivatives of Lei-Gong-Teng from Traditional Chinese Medicines 会议论文 作者:  Ren J(任进) 收藏  |  浏览/下载：22/0  |  提交时间：2019/01/08 Valuable model for clinical trail-System Toxicological Studies on Active Components in derivatives of Lei-Gong-Teng from Traditional Chinese Medicines   Synthesis of Aromatic Amide Derivatives and Their Biological Evaluation against Protein Tyrosine Phosphatase 1B and Scr Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 期刊论文 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 卷号: 36, 期号: 9, 页码: 2142-2149 作者:  Wang Wenlong;  Luo Huan;  Gao Ya;  Gao Lixin;  Sheng Li 收藏  |  浏览/下载：24/0  |  提交时间：2019/01/08 PTP1B  SHP2  aromatic amide derivatives  inhibitors