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Cyclic helix B peptide inhibits ischemia reperfusion-induced renal fibrosis via the PI3K/Akt/FoxO3a pathway 期刊论文
Journal of Translational Medicine, 2015, 卷号: 13
作者:  Yang, Cheng;  Cao, Ye;  Zhang, Yi;  Li, Long;  Xu, Ming
收藏  |  浏览/下载:21/0  |  提交时间:2019/01/08
The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review) 期刊论文
ONCOLOGY REPORTS, 2015, 卷号: 34, 期号: 2, 页码: 547-554
作者:  Luo, Xiangjian;  Yu, Xinfang;  Liu, Sufang;  Deng, Qipan;  Liu, Xiaolan
收藏  |  浏览/下载:35/0  |  提交时间:2015/12/17
MiR-138 suppresses airway smooth muscle cell proliferation through the PI3K/AKT signaling pathway by targeting PDK1 期刊论文
EXPERIMENTAL LUNG RESEARCH, 2015, 卷号: 41, 期号: [db:dc_citation_issue], 页码: 363-369
作者:  Liu, Yun;  Yang, Kunzheng;  Sun, Xiuzhen;  Fang, Ping;  Shi, Hongyang
收藏  |  浏览/下载:8/0  |  提交时间:2019/12/02
Expression of 3-phosphoinositide-dependent protein kinase 1 in colorectal cancer as a potential therapeutic target 期刊论文
2015, 卷号: 32, 期号: 7
作者:  Xu, Zhenglei[1];  Liao, Bihong[2];  Zhang, Ru[1];  Yao, Jun[1];  Shi, Ruiyue[1]
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/10
PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer 期刊论文
ONCOTARGET, 2015, 卷号: 6, 期号: 30
作者:  Lian, Shixian;  Shao, Yebo;  Liu, Houbao;  He, Junyi;  Lu, Weiqi
收藏  |  浏览/下载:6/0  |  提交时间:2019/12/13
Phosphoinositide-dependent kinase 1 regulates leukemia stem cell maintenance in MLL-AF9-induced murine acute myeloid leukemia 期刊论文
2015, 卷号: 459, 期号: 4, 页码: 692-698
作者:  Hu, Tianyuan;  Li, Cong;  Zhang, Yingchi;  Wang, Le;  Peng, Luyun
收藏  |  浏览/下载:3/0  |  提交时间:2020/01/13
PDK1  Akt  MLL-AF9  AML  LSCs  Apoptosis  
PI3K/Akt signaling in osteosarcoma 期刊论文
Clinica Chimica Acta, 2015, 卷号: 444, 期号: Volume 444, 页码: 182-192
作者:  Zhang, Jian;  Yu, Xiao-Hua;  Yan, Yi-Guo;  Wang, Cheng;  Wang, Wen-Jun*
收藏  |  浏览/下载:13/0  |  提交时间:2019/12/27
OS  osteosarcoma  PI3K  phosphatidylinositol 3-kinase  PTEN  phosphatase and tensin homolog  mTOR  mammalian target of rapamycin  RTKs  receptor tyrosine kinases  PDGFR  platelet-derived growth factor receptor  IGF1R  insulin-like growth factor 1 receptor  PIP2  phosphatidylinositol 4,5-biphosphate  PIP3  phosphatidylinositol 3,4,5-triphosphate  PDK1  phosphoinositide-dependent kinase 1  PH  pleckstrin homology  CDK  cyclin-dependent kinase  NF-κB  nuclear factor-κB  MDM2  Murine double minute 2  Rb  retinoblastoma  CSCs  cancer stem cells  CXCR7  CXC chemokine receptor 7  GA  gallic acid  miRNAs  microRNAs  TNF  tumor necrosis factor  HIF-1  hypoxia-inducible factor-1  ET-1  endothelin-1  ETAR  endothelin A receptor  MMP  matrix metalloproteinase.  OS  PI3K  Akt  PTEN  mTOR  
MicroRNAs: New players in intervertebral disc degeneration 期刊论文
Clinica Chimica Acta, 2015, 卷号: 450, 页码: 333-341
作者:  Wang, Cheng;  Wang, Wen-Jun;  Yan, Yi-Guo;  Xiang, Yong-Xiao;  Zhang, Jian
收藏  |  浏览/下载:22/0  |  提交时间:2019/12/27
IVD  intervertebral disc  NP  nucleus pulposus  AF  annulus fibrosus  CEPs  cartilaginous endplates  IDD  intervertebral disc degeneration  ECM  extracellular matrix  miRNAs  microRNAs  RNA pol  RNA polymerase  DGCR8  DiGeorge syndrome critical gene 8  Exp 5  exportin 5  TRBP  transactivating response RNA-binding protein  RISC  RNA-induced silencing complex  Ago  Argonaute  PI3K  phosphoinositide 3-kinase  MAPK  mitogen-activated protein kinase  TGF-β  transforming growth factor-β  PDGF  platelet-derived growth factor  IGF  insulin-like growth factor  EGF  epidermal growth factor  CDKI1B  cyclin-dependent kinase inhibitor 1B  TNF-α  tumor necrosis factor-α  FADD  Fas-associated death domain-containing protein  Col II  type II collagen  Col I  type I collagen  MMPs  matrix metalloproteinases  ADAMTSs  a disintegrin and metalloprotease with thrombospondin motifs  Col I  type I collagen  Col II  type II collagen  FGF2  fibroblast growth factor 2  FGFR  fibroblast growth factor receptor  IL-1β  interleukin-1β  NGF  nerve growth factor  HOXD10  homeobox D10  MiRNAs  IDD  NP cells  Apoptosis  Cell proliferation  


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