The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis)

	The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis)
	Meng, Xiaolin 1; Tian, Xue 1; Nie, Guoxing 1; Wang, Junli 1; Liu, Mei 2; Jiang, Keyong 2; Wang, Baojie 2; Guo, Qianqian 1; Huang, Jianrong 1; Wang, Lei 2
刊名	FISH & SHELLFISH IMMUNOLOGY
	2015-10-01
卷号	46 期号:2 页码:161-167
关键词	Mizuhopecten yessoensis Digestive gland Copper Deep-sequencing
英文摘要	The present study was conducted to elucidate the effects of copper exposure on the immune system and lipid metabolism of the Japanese scallop, Mizuhopecten yessoensts. Transcriptional levels of differentially expressed genes (DEGs)in M. yessoensis digestive gland tissue were analyzed using the deep-sequencing platform Illumina HiSeq (TM) 2000. In total, 841 and 877 genes were identified as significantly up- or down-regulated, respectively. In addition, significant enrichment analysis identified 3 gene ontology terms and 15 pathways involved in the response to copper exposure. Analysis of transcripts related to the immune response revealed a complex pattern of innate recognition receptors, including toll-like receptors, NOD-like receptors and downstream pathway effectors, including those involved in apoptosis. Furthermore, genomic analysis revealed that genes involved in extracellular matrix (ECM)-receptor interactions were enriched in Cu-exposed scallop glands. These results will provide a resource for subsequent gene expression studies regarding heavy metal exposure and the identification of copper-sensitive biomarkers for the aquaculture of M. yessoensis. (C) 2015 Elsevier Ltd. All rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000363071200001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/73940]
专题	海洋研究所_海洋生物技术研发中心
作者单位	1.Henan Normal Univ, Coll Fisheries, Xinxiang 453007, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, R&D Ctr Marine, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Meng, Xiaolin,Tian, Xue,Nie, Guoxing,et al. The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis)[J]. FISH & SHELLFISH IMMUNOLOGY,2015,46(2):161-167.
APA	Meng, Xiaolin.,Tian, Xue.,Nie, Guoxing.,Wang, Junli.,Liu, Mei.,...&Wang, Lei.(2015).The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis).FISH & SHELLFISH IMMUNOLOGY,46(2),161-167.
MLA	Meng, Xiaolin,et al."The transcriptomic response to copper exposure in the digestive gland of Japanese scallops (Mizuhopecten yessoensis)".FISH & SHELLFISH IMMUNOLOGY 46.2(2015):161-167.