NMR Based Cerebrum Metabonomic Analysis Reveals Simultaneous Interconnected Changes during Chick Embryo Incubation

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	NMR Based Cerebrum Metabonomic Analysis Reveals Simultaneous Interconnected Changes during Chick Embryo Incubation
	Feng, Yue 1,2; Zhu, Hang 1; Zhang, Xu 1; Wang, Xuxia 1; Xu, Fuqiang 1; Tang, Huiru 1; Ye, Chaohui 1; Liu, Maili 1
刊名	PLOS ONE
	2015-10-20
卷号	10 期号:10
英文摘要	To find out if content changes of the major functional cerebrum metabolites are interconnected and formed a network during the brain development, we obtained high-resolution magic-angle-spinning (HR-MAS) H-1 NMR spectra of cerebrum tissues of chick embryo aged from incubation day 10 to 20, and postnatal day 1, and analyzed the data with principal component analysis (PCA). Within the examined time window, 26 biological important molecules were identified and 12 of them changed their relative concentration significantly in a time-dependent manner. These metabolites are generally belonged to three categories, neurotransmitters, nutrition sources, and neuronal or glial markers. The relative concentration changes of the metabolites were interconnected among/between the categories, and, more interestingly, associated with the number and size of Nissl-positive neurons. These results provided valuable biochemical and neurochemical information to understand the development of the embryonic brain.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	MAGNETIC-RESONANCE-SPECTROSCOPY ; PROTON MR SPECTROSCOPY ; HUMAN FETAL BRAIN ; FREE AMINO-ACIDS ; IN-VIVO ; RAT-BRAIN ; NEUROCHEMICAL PROFILE ; H-1-NMR SPECTROSCOPY ; H-1 ; METABOLITE
收录类别	SCI
语种	英语
WOS记录号	WOS:000363028100018
公开日期	2015-12-22
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/9024]
专题	武汉物理与数学研究所_磁共振基础研究部
作者单位	1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA
推荐引用方式 GB/T 7714	Feng, Yue,Zhu, Hang,Zhang, Xu,et al. NMR Based Cerebrum Metabonomic Analysis Reveals Simultaneous Interconnected Changes during Chick Embryo Incubation[J]. PLOS ONE,2015,10(10).
APA	Feng, Yue.,Zhu, Hang.,Zhang, Xu.,Wang, Xuxia.,Xu, Fuqiang.,...&Liu, Maili.(2015).NMR Based Cerebrum Metabonomic Analysis Reveals Simultaneous Interconnected Changes during Chick Embryo Incubation.PLOS ONE,10(10).
MLA	Feng, Yue,et al."NMR Based Cerebrum Metabonomic Analysis Reveals Simultaneous Interconnected Changes during Chick Embryo Incubation".PLOS ONE 10.10(2015).