EGFP-Based Protein Nanoparticles with Cell-Penetrating Peptide for Efficient siRNA Delivery

	EGFP-Based Protein Nanoparticles with Cell-Penetrating Peptide for Efficient siRNA Delivery
	Guan, Xingang 1,2; Hu, Xiuli 1; Cui, Fengchao 3; Li, Yunqi 3; Jing, Xiabing 1; Xie, Zhigang 1
刊名	MACROMOLECULAR BIOSCIENCE
	2015-11-01
卷号	15 期号:11 页码:1484-1489
关键词	protein nanoparticle siRNA delivery tat
英文摘要	Development of an innovative nucleic acid nanocarriers still represents a challenge. In this study, we develop a protein nanoparticle (H6-TatEGFP) and examine its siRNA condensing activity. Gel retardation assay show that protein nanoparticle can condense siRNA into stable nanoparticle/siRNA complexes. UsingCy3-labelled siRNA, we also evaluate siRNA transport characteristic of protein nanoparticles in tumor cells, the results indicate that H6-TatEGFP nanoparticle may be a potential nanocarrier for siRNA in tumor cells.
收录类别	SCI
语种	英语
公开日期	2015-12-22
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/29170]
专题	化学研究所_高分子物理与化学实验室
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Beihua Univ, Life Sci Res Ctr, Jilin 132013, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Synthet Rubber, Changchun 130022, Peoples R China
推荐引用方式 GB/T 7714	Guan, Xingang,Hu, Xiuli,Cui, Fengchao,et al. EGFP-Based Protein Nanoparticles with Cell-Penetrating Peptide for Efficient siRNA Delivery[J]. MACROMOLECULAR BIOSCIENCE,2015,15(11):1484-1489.
APA	Guan, Xingang,Hu, Xiuli,Cui, Fengchao,Li, Yunqi,Jing, Xiabing,&Xie, Zhigang.(2015).EGFP-Based Protein Nanoparticles with Cell-Penetrating Peptide for Efficient siRNA Delivery.MACROMOLECULAR BIOSCIENCE,15(11),1484-1489.
MLA	Guan, Xingang,et al."EGFP-Based Protein Nanoparticles with Cell-Penetrating Peptide for Efficient siRNA Delivery".MACROMOLECULAR BIOSCIENCE 15.11(2015):1484-1489.