Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents
	Feng, JH ; Sun, GY ; Pei, FK ; Liu, ML
刊名	BIOORGANIC & MEDICINAL CHEMISTRY
	2003-07-31
卷号	11 期号:15 页码:3359-3366
英文摘要	Four neutral gadolinium complexes of diethylenetriaminepentaacetic acid (DTPA)-bisamide derivatives have been synthesized and characterized. Their potential application as tissue-specific and low-osmolarity MRI contrast agents has been evaluated by in vitro and in vivo experiments. Their measured relaxivities in D2O, bovine serum albumin and human serum transferrin solutions showed favorable relaxation ability. In vivo studies have proven that Gd(DTPA-BDMA), Gd(DTPA-BIN), and Gd(cyclic-DTPA-1,2-pn) could be promising liver-specific MRI contrast agents and Gd(DTPA-BDMA), and Gd(cyclic-DTPA-1,2-pn) have favorable renal excretion capability. Among them, Gd(cyclic-DTPA-1,2-pn) is a more powerful hepatic contrast agent and Gd(DTPA-BIN) provides the stable imaging contrast for several hours. They also show a lower toxicity. (C) 2003 Elsevier Science Ltd. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]	Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]	DIETHYLENETRIAMINEPENTAACETIC ACID BIS(METHYLAMIDE) ; SERUM-ALBUMIN SOLUTION ; BLOOD-POOL AGENT ; MAGNETIC-RESONANCE ; LANTHANIDE(III) COMPLEXES ; GADOLINIUM(III) COMPLEXES ; RELAXATION ; DYNAMICS ; LIGAND ; GDDTPA
收录类别	SCI
语种	英语
WOS记录号	WOS:000183935400015
公开日期	2015-12-08
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/8907]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Feng, JH,Sun, GY,Pei, FK,et al. Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2003,11(15):3359-3366.
APA	Feng, JH,Sun, GY,Pei, FK,&Liu, ML.(2003).Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents.BIOORGANIC & MEDICINAL CHEMISTRY,11(15),3359-3366.
MLA	Feng, JH,et al."Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents".BIOORGANIC & MEDICINAL CHEMISTRY 11.15(2003):3359-3366.