Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents | |
Feng, JH; Sun, GY; Pei, FK; Liu, ML | |
刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
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2003-07-31 | |
卷号 | 11期号:15页码:3359-3366 |
英文摘要 | Four neutral gadolinium complexes of diethylenetriaminepentaacetic acid (DTPA)-bisamide derivatives have been synthesized and characterized. Their potential application as tissue-specific and low-osmolarity MRI contrast agents has been evaluated by in vitro and in vivo experiments. Their measured relaxivities in D2O, bovine serum albumin and human serum transferrin solutions showed favorable relaxation ability. In vivo studies have proven that Gd(DTPA-BDMA), Gd(DTPA-BIN), and Gd(cyclic-DTPA-1,2-pn) could be promising liver-specific MRI contrast agents and Gd(DTPA-BDMA), and Gd(cyclic-DTPA-1,2-pn) have favorable renal excretion capability. Among them, Gd(cyclic-DTPA-1,2-pn) is a more powerful hepatic contrast agent and Gd(DTPA-BIN) provides the stable imaging contrast for several hours. They also show a lower toxicity. (C) 2003 Elsevier Science Ltd. All rights reserved. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic |
研究领域[WOS] | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
关键词[WOS] | DIETHYLENETRIAMINEPENTAACETIC ACID BIS(METHYLAMIDE) ; SERUM-ALBUMIN SOLUTION ; BLOOD-POOL AGENT ; MAGNETIC-RESONANCE ; LANTHANIDE(III) COMPLEXES ; GADOLINIUM(III) COMPLEXES ; RELAXATION ; DYNAMICS ; LIGAND ; GDDTPA |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000183935400015 |
公开日期 | 2015-12-08 |
内容类型 | 期刊论文 |
源URL | [http://ir.wipm.ac.cn/handle/112942/8907] ![]() |
专题 | 武汉物理与数学研究所_2011年以前论文发表(包括2011年) |
作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
推荐引用方式 GB/T 7714 | Feng, JH,Sun, GY,Pei, FK,et al. Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2003,11(15):3359-3366. |
APA | Feng, JH,Sun, GY,Pei, FK,&Liu, ML.(2003).Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents.BIOORGANIC & MEDICINAL CHEMISTRY,11(15),3359-3366. |
MLA | Feng, JH,et al."Comparison between Gd-DTPA and several bisamide derivatives as potential MRI contrast agents".BIOORGANIC & MEDICINAL CHEMISTRY 11.15(2003):3359-3366. |
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