Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases

	Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases
	Ai, Limei 1; Zhu, Liangliang 2; Yang, Lu 3; Ge, Guangbo 4,5; Cao, Yunfeng 4,5; Liu, Yong 4,5; Fang, Zhongze 4,5; Zhang, Yanyan 4,5
刊名	xenobiotica
	2014-04-01
卷号	44 期号:4 页码:320-325
关键词	Niloinib the selective inhibitor UDP-glucuronosyltransferase 1A1
英文摘要	1. nilotinib, a tyrosine kinase inhibitor, could potently inhibit sn-38 glucuronidation mainly catalyzed by udp-glucuronosyltransferase (ugt) 1a1. this study was designed to investigate whether nilotinib can be used as a selective inhibitor of ugt1a1 in human liver.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	pharmacology & pharmacy ; toxicology
研究领域[WOS]	pharmacology & pharmacy ; toxicology
关键词[WOS]	tyrosine kinase inhibitors ; drug-glucuronidation ; phenylbutazone ; polymorphism ; prediction ; substrate ; kinetics ; isoform ; probes
收录类别	SCI
语种	英语
WOS记录号	WOS:000332738200003
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/143206]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Liaoning Med Univ, Affiliated Hosp 1, Dept Hematol, Jinzhou 121001, Peoples R China 2.Anqing Normal Univ, Sch Life Sci, Dept Quarantine Anim & Plants, Anqing, Peoples R China 3.Liaoning Univ Tradit Chinese Med, Sch Pharm, Dept Anal Chinese Med, Dalian, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Joint Ctr Translat Med, Dalian, Peoples R China 5.Liaoning Med Univ, Affiliated Hosp 1, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Ai, Limei,Zhu, Liangliang,Yang, Lu,et al. Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases[J]. xenobiotica,2014,44(4):320-325.
APA	Ai, Limei.,Zhu, Liangliang.,Yang, Lu.,Ge, Guangbo.,Cao, Yunfeng.,...&Zhang, Yanyan.(2014).Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases.xenobiotica,44(4),320-325.
MLA	Ai, Limei,et al."Selectivity for inhibition of nilotinib on the catalytic activity of human UDP-glucuronosyltransferases".xenobiotica 44.4(2014):320-325.