Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta

	Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta
	Zhang, Hong 1; Zhang, Dan-Dan 3; Lao, Yuan-Zhi 1; Fu, Wen-Wei 1; Liang, Shuang 1; Yuan, Qing-Hong 4; Yang, Ling 5; Xu, Hong-Xi 1,2
刊名	journal of natural products
	2014-07-01
卷号	77 期号:7 页码:1700-1707
英文摘要	five new prenylated benzoylphloroglucinol derivatives, garciesculentones a-e (1-5), a new xanthone, garciesculenxanthone a (6), and 15 known compounds were isolated from the petroleum ether extract and the etoac-soluble fraction of a 80% (v/v) etoh extract of garcinia esculenta. the structures of the new compounds were elucidated by 1d- and 2d-nmr spectroscopic analysis and mass spectrometry. experimental and calculated ecd and a convenient modified mosher's method were used to determine the absolute configurations. the cytotoxicity of these compounds were evaluated by mtt assay against three human cancer cell lines (hepg2, mcf-7, and mda-mb-231) and against normal hepatic cells (hl-7702). in addition, these isolates were evaluated for their inhibitory effects on interferon-gamma plus lipopolysaccharide-induced nitric oxide production in raw264.7 cells.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	plant sciences ; chemistry, medicinal ; pharmacology & pharmacy
研究领域[WOS]	plant sciences ; pharmacology & pharmacy
关键词[WOS]	bioassay-guided isolation ; colon-cancer cells ; gamma-mangostin ; polyprenylated xanthones ; benzophenone derivatives ; absolute-configuration ; natural-products ; oblongifolia ; leaves ; fruits
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000339604300021
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/143171]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 2.Shanghai Coll TCM New Drug Discovery, Engn Res Ctr, Shanghai 201203, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Murad Res Ctr Modernized Chinese Med, Shanghai 201203, Peoples R China 4.E China Normal Univ, Dept Phys, Shanghai 200241, Peoples R China 5.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hong,Zhang, Dan-Dan,Lao, Yuan-Zhi,et al. Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta[J]. journal of natural products,2014,77(7):1700-1707.
APA	Zhang, Hong.,Zhang, Dan-Dan.,Lao, Yuan-Zhi.,Fu, Wen-Wei.,Liang, Shuang.,...&Xu, Hong-Xi.(2014).Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta.journal of natural products,77(7),1700-1707.
MLA	Zhang, Hong,et al."Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta".journal of natural products 77.7(2014):1700-1707.