Evaluation of "click" binaphthyl chiral stationary phases by liquid chromatography

	Evaluation of "click" binaphthyl chiral stationary phases by liquid chromatography
	Yu, Hui 1; Yin, Chenghua 1; Jia, Cunyu 1; Jin, Yu 1; Ke, Yanxiong 1; Liang, Xinmiao 2
刊名	chirality
	2012-05-01
卷号	24 期号:5 页码:391-399
关键词	chiral stationary phases click chemistry binaphthyl p-p interaction thermodynamic parameters
英文摘要	two click binaphthyl chiral stationary phases were synthesized and evaluated by liquid chromatography. their structures incorporate s-(-)-1,1'-binaphthyl moiety as the chiral selector and 1,2,3-triazole ring as the spacer. these chiral stationary phases (csps) allowed the efficient resolution for a wide range of racemic binol derivatives, particularly for nonpolar diether derivatives and 3-phenyl indolin-2-one analogs. the chromatographic data showed that the pp interaction was crucial for enantiorecognition of these csps. loss of enantioselectivity observed on csp3, which are lacking the triazole ring linkage, indicated that the triazole ring linkage took part in the enantioseparation process, although it was remote from the chiral selector of the csp. the substitution of the phenyl group at 6 and 6' positions can significantly improve the separation ability of the csp. the chiral recognition mechanism was also investigated by tracking the elution orders and studying the thermodynamic parameters. chirality 24:391399, 2012. copyright (c) 2012 wiley periodicals, inc.
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]	chemistry, medicinal ; chemistry, analytical ; chemistry, organic ; pharmacology & pharmacy
研究领域[WOS]	pharmacology & pharmacy ; chemistry
关键词[WOS]	silica-gel ; efficient resolution ; acid-derivatives ; enantioseparation ; separation ; enantiomers ; recognition ; temperature ; mechanism ; binol
收录类别	SCI
语种	英语
WOS记录号	WOS:000303237200006
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/143073]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.E China Univ Sci & Technol, Sch Pharm, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Yu, Hui,Yin, Chenghua,Jia, Cunyu,et al. Evaluation of "click" binaphthyl chiral stationary phases by liquid chromatography[J]. chirality,2012,24(5):391-399.
APA	Yu, Hui,Yin, Chenghua,Jia, Cunyu,Jin, Yu,Ke, Yanxiong,&Liang, Xinmiao.(2012).Evaluation of "click" binaphthyl chiral stationary phases by liquid chromatography.chirality,24(5),391-399.
MLA	Yu, Hui,et al."Evaluation of "click" binaphthyl chiral stationary phases by liquid chromatography".chirality 24.5(2012):391-399.