Plasma Pharmacokinetics and Tissue Distribution of Arctiin and Its Main Metabolite in Rats by HPLC-UV and LC-MS

	Plasma Pharmacokinetics and Tissue Distribution of Arctiin and Its Main Metabolite in Rats by HPLC-UV and LC-MS
	He Fan 1,2; Dou De-Qiang 2; Sun Yu 2; Zhu Lin 3; Xiao Hong-Bin 3; Kang Ting-Guo 1
刊名	planta medica
	2012-05-01
卷号	78 期号:8 页码:800-806
关键词	arctiin arctigenin HPLC-MS pharmacokinetics tissue distribution Arctium lappa Compositae
英文摘要	the pharmacokinetic profile of arctiin, the major active lignan in fruits of arctium lappa l., was investigated. its main metabolite arctigenin was identified by an lc-ms method, and an hplc-uv technique was developed for the simultaneous quantification of the metabolite and arctiin in plasma and organs. chromatographic separation was performed on an agilent (tm) c-18 hplc column with acetonitrile and water by linear gradient elution. arctiin and arctigenin were identified online by lc-ms. the pharmacokinetics and tissue distribution of arctiin and arctigenin were determined for the first time by using a simple, selective, and accurate hplc method. the auc(0-t) values of arctigenin were larger compared with arctiin after oral administration of arctiin. the concentration of the metabolite was significantly higher than the concentration of arctiin in the stomach and small intestine in rats after oral administration of arctiin, indicating that the stomach and small intestine were the major organs of arctiin metabolism. these findings could provide support for the clinical studies conducted with fructus arctii.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	plant sciences ; chemistry, medicinal ; pharmacology & pharmacy
研究领域[WOS]	plant sciences ; pharmacology & pharmacy
关键词[WOS]	sprague-dawley rats ; transformation ; arctigenin ; lignans ; mammary ; l.
收录类别	SCI
语种	英语
WOS记录号	WOS:000304449300010
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/142966]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Liaoning Univ Tradit Chinese Med, Dept Pharmacognosy, Dalian 116600, Peoples R China 2.Liaoning Univ Tradit Chinese Med, Dept Chinese Med Chem, Dalian 116600, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian, Peoples R China
推荐引用方式 GB/T 7714	He Fan,Dou De-Qiang,Sun Yu,et al. Plasma Pharmacokinetics and Tissue Distribution of Arctiin and Its Main Metabolite in Rats by HPLC-UV and LC-MS[J]. planta medica,2012,78(8):800-806.
APA	He Fan,Dou De-Qiang,Sun Yu,Zhu Lin,Xiao Hong-Bin,&Kang Ting-Guo.(2012).Plasma Pharmacokinetics and Tissue Distribution of Arctiin and Its Main Metabolite in Rats by HPLC-UV and LC-MS.planta medica,78(8),800-806.
MLA	He Fan,et al."Plasma Pharmacokinetics and Tissue Distribution of Arctiin and Its Main Metabolite in Rats by HPLC-UV and LC-MS".planta medica 78.8(2012):800-806.