MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status

	MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status
	Li, Wei 1,2; Liu, Yong 1; Li, Xue-Xia 3; Yu, Yang 1; Wu, Jing-Jing 1; Wang, Qing 4; Huo, Hong 1; Wang, Li-Ming 5; Yang, Ling 1
刊名	planta medica
	2011
卷号	77 期号:1 页码:27-31
关键词	triptolide Tripterygium wilfordii Celastraceae prostate cancer p53 mitogen activated protein kinases (MAPKs)
英文摘要	triptolide showed excellent antitumor activity against several solid tumors. however, its mechanism has not been fully understood. to further elucidate it, the effects of mitogen activated protein kinases (mapks) on the activity of triptolide towards prostate cancer cell lines were investigated in the present study using both lncap (p53 positive and androgen-dependent) and pc-3 (p53 deficient and androgen-independent) cells. our results showed that triptolide exerted potent growth inhibitory and apoptotic effects on both cell lines, and the effects were independent of the expression of p53. although upregulation of erk and jnk phosphorylation was observed after the triptolide treatment, the results with inhibitors showed that these mapks were not involved in the mechanism of triptolide activity in human prostate cancer cell lines with different p53 status.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	plant sciences ; chemistry, medicinal ; pharmacology & pharmacy
研究领域[WOS]	plant sciences ; pharmacology & pharmacy
关键词[WOS]	epithelial-cells ; primary cultures ; drug-resistance ; activation ; kinase ; pathways ; protein ; p38 ; phosphorylation ; chemotherapy
收录类别	SCI
语种	英语
WOS记录号	WOS:000285406500005
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/142556]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 3.Dalian Univ, Affiliated Zhongshan Hosp, Dept Oncol, Dalian, Peoples R China 4.Dalian Univ Technol, Dalian, Peoples R China 5.Dalian Med Univ, Affiliated Hosp 2, Dept Gen Surg, Dalian 116027, Peoples R China
推荐引用方式 GB/T 7714	Li, Wei,Liu, Yong,Li, Xue-Xia,et al. MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status[J]. planta medica,2011,77(1):27-31.
APA	Li, Wei.,Liu, Yong.,Li, Xue-Xia.,Yu, Yang.,Wu, Jing-Jing.,...&Yang, Ling.(2011).MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status.planta medica,77(1),27-31.
MLA	Li, Wei,et al."MAPKs Are Not Involved in Triptolide-Induced Cell Growth Inhibition and Apoptosis in Prostate Cancer Cell Lines with Different p53 Status".planta medica 77.1(2011):27-31.