Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion

	Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion
	Yang, Yan 2,3; Liu, Xiudong 1; Yu, Weiting 2; Zhou, Houjiang 2,3; Li, Xiaoxia 2,3; Ma, Xiaojun 2
刊名	carbohydrate polymers
	2010-05-05
卷号	80 期号:3 页码:733-739
关键词	Homogeneous synthesis Chitosan Hydroxyl Photochemistry Cell adhesion
英文摘要	a novel homogeneous synthesis route was presented to produce rgd-containing peptide modified chitosan (cts) with purpose of improving cell adhesion and growth. bifunctional photosensitive crosslinker, sulfo-sanpah, was used to link cell adhesive peptide grgdy and cts under controlled condition. the synthesis process was proved by ftir, maldi-tof ms and (1)h nmr analyses, and the mechanism was demonstrated clearly and completely that hydroxyl groups of cts were prior: to amino groups for nucleophilic reaction with sulfo-sanpah. moreover, cell adhesion and proliferation were evaluated for grgdy grafted cts. the results showed that grgdy grafted cts formed by the novel strategy had potential application not only as drug or gene carriers but also as tissue engineered scaffolds. (c) 2009 elsevier ltd. all rights reserved.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, applied ; chemistry, organic ; polymer science
研究领域[WOS]	chemistry ; polymer science
关键词[WOS]	arg-gly-asp ; human endothelial-cells ; in-vivo ; chitosan-graft-poly(ethylene glycol) ; drug-delivery ; rgd peptide ; growth ; surface ; proliferation ; nanoparticle
收录类别	SCI
语种	英语
WOS记录号	WOS:000276987800015
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/141786]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Yang, Yan,Liu, Xiudong,Yu, Weiting,et al. Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion[J]. carbohydrate polymers,2010,80(3):733-739.
APA	Yang, Yan,Liu, Xiudong,Yu, Weiting,Zhou, Houjiang,Li, Xiaoxia,&Ma, Xiaojun.(2010).Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion.carbohydrate polymers,80(3),733-739.
MLA	Yang, Yan,et al."Homogeneous synthesis of GRGDY grafted chitosan on hydroxyl groups by photochemical reaction for improved cell adhesion".carbohydrate polymers 80.3(2010):733-739.