C-7 configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes | |
Zhang, Y. -Y.1,3; Liu, Y.1; Zhang, J. -W.1; Ge, G. -B.1; Liu, H. -X.1,3; Wang, L. -M.2; Sun, J.2; Yang, L.1 | |
刊名 | xenobiotica |
2009-12-01 | |
卷号 | 39期号:12页码:903-914 |
关键词 | 7-Epi-cephalomannine 7-epi-10-deacetyl-paclitaxel paclitaxel cytochrome P450 structure-metabolism relationships metabolism |
英文摘要 | 1. taxanes exhibit a high tendency to epimerize at c-7 under physiological conditions. this study aimed to investigate the composite effect of c-7 configuration and other substructural elements on the metabolic properties of taxanes. cephalomannine, 7-epi-cephalomannine, 10-deacetyl-paclitaxel, and 7-epi-10-deacetyl-paclitaxel were chosen as model compounds. |
WOS标题词 | science & technology ; life sciences & biomedicine |
类目[WOS] | pharmacology & pharmacy ; toxicology |
研究领域[WOS] | pharmacology & pharmacy ; toxicology |
关键词[WOS] | ionization mass-spectrometry ; in-vitro metabolism ; liver-microsomes ; paclitaxel pharmacokinetics ; regioselective metabolism ; cyclophosphamide ; degradation ; specificity ; docetaxel ; substrate |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000272618900003 |
公开日期 | 2015-11-17 |
内容类型 | 期刊论文 |
源URL | [http://159.226.238.44/handle/321008/141444] |
专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 2.Dalian Med Univ, Affiliated Hosp 2, Dalian, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Y. -Y.,Liu, Y.,Zhang, J. -W.,et al. C-7 configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes[J]. xenobiotica,2009,39(12):903-914. |
APA | Zhang, Y. -Y..,Liu, Y..,Zhang, J. -W..,Ge, G. -B..,Liu, H. -X..,...&Yang, L..(2009).C-7 configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes.xenobiotica,39(12),903-914. |
MLA | Zhang, Y. -Y.,et al."C-7 configuration as one of determinants in taxanes metabolism by human cytochrome P450 enzymes".xenobiotica 39.12(2009):903-914. |
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