Preparation of novel bovine hemoglobin surface-imprinted polystyrene nanoparticles with magnetic susceptibility

	Preparation of novel bovine hemoglobin surface-imprinted polystyrene nanoparticles with magnetic susceptibility
	Li Lin 1,2; He XiWen 1; Chen LangXing 1; Zhang YuKui 1,3
刊名	science in china series b-chemistry
	2009-09-01
卷号	52 期号:9 页码:1402-1411
关键词	magnetic nanoparticles protein molecular imprinting poly(3-aminophenylboronic acid) thin films selective adsorption
英文摘要	in this research, a surface imprinting strategy has been adopted in protein imprinting. bovine hemoglobin surface-imprinted polystyrene (ps) nanoparticles with magnetic susceptibility have been synthesized through multistage core-shell polymerization system using 3-aminophenylboronic acid (apba) as functional and cross-linking monomers. superparamagnetic molecularly imprinted polystyrene nanospheres with poly(apba) thin films have been synthesized and used for the first time for protein molecular imprinting in an aqueous solution. the magnetic susceptibility is imparted through the successful encapsulation of fe(3)o(4) nanoparticles. the morphology, adsorption, and recognition properties of superparamagnetic molecularly imprinted polymers (mips) have been investigated using transmission electron microscopy, x-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometer. rebinding experimental results show that poly(apba) mips-coated superparamagnetic ps nanoparticles have high adsorption capacity for template protein bovine hemoglobin and comparatively low nonspecific adsorption. the imprinted superparamagnetic nanoparticles could easily reach the adsorption equilibrium and achieve magnetic separation in an external magnetic field, thus avoiding some problems of the bulk polymer.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, multidisciplinary
研究领域[WOS]	chemistry
关键词[WOS]	iron-oxide nanoparticles ; protein recognition ; serum-albumin ; thin-films ; polymers ; microspheres ; adsorption ; separation ; binding ; beads
收录类别	SCI
语种	英语
WOS记录号	WOS:000270191100016
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/141318]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Nankai Univ, Coll Chem, Tianjin 300071, Peoples R China 2.Nankai Univ, Coll Pharmaceut Sci, Tianjin 300071, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116011, Peoples R China
推荐引用方式 GB/T 7714	Li Lin,He XiWen,Chen LangXing,et al. Preparation of novel bovine hemoglobin surface-imprinted polystyrene nanoparticles with magnetic susceptibility[J]. science in china series b-chemistry,2009,52(9):1402-1411.
APA	Li Lin,He XiWen,Chen LangXing,&Zhang YuKui.(2009).Preparation of novel bovine hemoglobin surface-imprinted polystyrene nanoparticles with magnetic susceptibility.science in china series b-chemistry,52(9),1402-1411.
MLA	Li Lin,et al."Preparation of novel bovine hemoglobin surface-imprinted polystyrene nanoparticles with magnetic susceptibility".science in china series b-chemistry 52.9(2009):1402-1411.