Functional analysis of cultured neural cells for evaluating cold/cool- and hot/warm-natured Chinese herbs

	Functional analysis of cultured neural cells for evaluating cold/cool- and hot/warm-natured Chinese herbs
	Liu, Yan-Qiu 1; Cheng, Meng-Chun 1; Wang, Long-Xing 1; Zhao, Nan 1; Xiao, Hong-Bin 1; Wang, Zheng-Tao 2
刊名	american journal of chinese medicine
	2008
卷号	36 期号:4 页码:771-781
关键词	Chinese herbs four properties antioxidant activity glucose uptake norepinephrine
英文摘要	recently, modern scientific research has been required to understand pharmacological basis of traditional chinese medicine (tcm) theory based on the ancient clinical experience, and to investigate the molecular mechanisms of action of chinese herbs. here, 20 chinese herbs, classified into 4 properties (hot, warm, cold and cool) of tcm, were analyzed for their ability to exhibit antioxidant action, to enhance glucose uptake by murine microglia n9 cells, and to influence neurotransmitter norepinephrine (ne) release from rat pheochromocytoma pc12 cells. we found a generally protective effect of both hot/warm-natured and cold/cool-natured herbs against h(2)o(2)-induced n9 cell death, partially by elevating superoxide dismutase (sod) activity. glucose uptake was elevated after treatment with some hot/warm-natured herbs. in addition, most herbs with hot/warm nature tended to stimulate ne release, while such stimulatory effect was not observed in the herbs with cold/cool nature. two cold/cool-natured herbs, rhizoma coptidis and radix scutellariae, even significantly suppressed the release. these results suggest that the distinct abilities of chinese herbs to regulate neural cell functions appear to be correlated with their natures identified in traditional tcm theory, and may be a useful guide for their utility in neural degenerative diseases.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	integrative & complementary medicine ; medicine, general & internal
研究领域[WOS]	integrative & complementary medicine ; general & internal medicine
关键词[WOS]	alzheimers-disease ; oxidative stress ; beta ; deficiency ; diagnosis ; model
收录类别	SCI
语种	英语
WOS记录号	WOS:000258793200013
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/141090]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Shanghai Univ TCM, Key Lab Standardizat Chinese Med, Minist Educ,Inst Chinese Mat Med, Shanghai R&D Ctr Standardizat Chinese Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yan-Qiu,Cheng, Meng-Chun,Wang, Long-Xing,et al. Functional analysis of cultured neural cells for evaluating cold/cool- and hot/warm-natured Chinese herbs[J]. american journal of chinese medicine,2008,36(4):771-781.
APA	Liu, Yan-Qiu,Cheng, Meng-Chun,Wang, Long-Xing,Zhao, Nan,Xiao, Hong-Bin,&Wang, Zheng-Tao.(2008).Functional analysis of cultured neural cells for evaluating cold/cool- and hot/warm-natured Chinese herbs.american journal of chinese medicine,36(4),771-781.
MLA	Liu, Yan-Qiu,et al."Functional analysis of cultured neural cells for evaluating cold/cool- and hot/warm-natured Chinese herbs".american journal of chinese medicine 36.4(2008):771-781.