Efficient enzymatic regioselective benzoylation of 5-fluorouridine catalysed by Novozym 435

	Efficient enzymatic regioselective benzoylation of 5-fluorouridine catalysed by Novozym 435
	Wu, Jian 1,2; Zong, Min-Hua 1; Wu, Hong 1; Lou, Wen-Yong 1
刊名	journal of chemical technology and biotechnology
	2008-06-01
卷号	83 期号:6 页码:814-820
关键词	Novozym 435 regioselective acylation 5-fluorouridine 5'-O-benzoyl-5-fluorouridine vinyl benzoate co-solvent
英文摘要	background: this work focuses on developing a mild, efficient and regioselective enzymatic procedure to synthesise 5'-o-benzoyl-5-fluorouridine, a more powerful antitumour drug than 5-fluorouridine itself, and examining the influences of several key variables on the reaction.
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences ; technology
类目[WOS]	biotechnology & applied microbiology ; chemistry, multidisciplinary ; engineering, chemical
研究领域[WOS]	biotechnology & applied microbiology ; chemistry ; engineering
关键词[WOS]	organic-solvents ; water activity ; antitumor-activity ; nonaqueous media ; lipase ; nucleosides ; derivatives ; acylation ; mild ; 1-beta-d-arabinofuranosylcytosine
收录类别	SCI
语种	英语
WOS记录号	WOS:000256203400007
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/140972]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.S China Univ Technol, Lab Appl Biocatalysis, Guangzhou 510640, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Wu, Jian,Zong, Min-Hua,Wu, Hong,et al. Efficient enzymatic regioselective benzoylation of 5-fluorouridine catalysed by Novozym 435[J]. journal of chemical technology and biotechnology,2008,83(6):814-820.
APA	Wu, Jian,Zong, Min-Hua,Wu, Hong,&Lou, Wen-Yong.(2008).Efficient enzymatic regioselective benzoylation of 5-fluorouridine catalysed by Novozym 435.journal of chemical technology and biotechnology,83(6),814-820.
MLA	Wu, Jian,et al."Efficient enzymatic regioselective benzoylation of 5-fluorouridine catalysed by Novozym 435".journal of chemical technology and biotechnology 83.6(2008):814-820.