A multichannel electrophoresis microchip platform for rapid chiral selector screening

	A multichannel electrophoresis microchip platform for rapid chiral selector screening
	Gao, Yan; Luo, Yong; Qin, Jianhua; Lin, Bingcheng
刊名	electrophoresis
	2008-05-01
卷号	29 期号:9 页码:1918-1923
关键词	chiral selector cycloclextrin high throughput microchip electrophoresis screening
英文摘要	this study presents a four-channel electrophoresis chip platform, featuring double-cross hydrostatic sample injection, for rapid chiral selector screening. this platform needs only five electrodes to drive microchip electrophoresis in four separate channels for screening four chiral selectors at a time. to demonstrate the performance of this screening platform, eight neutral cds and their derivatives as chiral selectors were screened towards two fitc-labeled chiral compounds. the screening could be accomplished in less than 2 min. dimethyl-beta-cd and hydroxypropyl-alpha-cd was demonstrated to be the appropriate selectors for fitc-norfenefrine and fitc-baclofen, respectively. the established platform is easy to operate and suitable for rapid screening process, which is expected to be a potential platform for high-throughput screening of chiral selectors.
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]	biochemical research methods ; chemistry, analytical
研究领域[WOS]	biochemistry & molecular biology ; chemistry
关键词[WOS]	nuclear-magnetic-resonance ; capillary-electrophoresis ; enantiomeric separation ; on-chip ; enantioselective catalysis ; combinatorial library ; liquid-chromatography ; microfluidic chip ; cyclodextrins ; strategy
收录类别	SCI
语种	英语
WOS记录号	WOS:000256510000019
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/140910]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Gao, Yan,Luo, Yong,Qin, Jianhua,et al. A multichannel electrophoresis microchip platform for rapid chiral selector screening[J]. electrophoresis,2008,29(9):1918-1923.
APA	Gao, Yan,Luo, Yong,Qin, Jianhua,&Lin, Bingcheng.(2008).A multichannel electrophoresis microchip platform for rapid chiral selector screening.electrophoresis,29(9),1918-1923.
MLA	Gao, Yan,et al."A multichannel electrophoresis microchip platform for rapid chiral selector screening".electrophoresis 29.9(2008):1918-1923.