Synthesis and activity of the photoaffinity-labeled functional probe based on prenyl side-chain

	Synthesis and activity of the photoaffinity-labeled functional probe based on prenyl side-chain
	Li Ling-Dong; Tang Wei; Liu Wu-Jun; Zhao Zong-Bao
刊名	chinese journal of organic chemistry
	2008-03-01
卷号	28 期号:3 页码:489-493
关键词	prenyl side-chain functional probe photoaffinity labeling chemical proteomics
英文摘要	a novel functional probe bearing both a benzophenone moiety and a biotin moiety was synthesized in 5 steps with an overall yield of 9%. photoaffinity labeling and biotin blot experiment with the probe and the crude protein extracts from saccharomyces cerevisiae as 2.399 revealed that the synthetic probe was attached to a number of proteins, providing a basis for further chemical proteomics research.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, organic
研究领域[WOS]	chemistry
关键词[WOS]	protein farnesyltransferase ; farnesyl transferase ; diphosphate analogs ; chemical strategies ; prenyltransferases ; inhibitors ; proteomics ; reagents
收录类别	SCI
语种	英语
WOS记录号	WOS:000254422500023
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/140786]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Li Ling-Dong,Tang Wei,Liu Wu-Jun,et al. Synthesis and activity of the photoaffinity-labeled functional probe based on prenyl side-chain[J]. chinese journal of organic chemistry,2008,28(3):489-493.
APA	Li Ling-Dong,Tang Wei,Liu Wu-Jun,&Zhao Zong-Bao.(2008).Synthesis and activity of the photoaffinity-labeled functional probe based on prenyl side-chain.chinese journal of organic chemistry,28(3),489-493.
MLA	Li Ling-Dong,et al."Synthesis and activity of the photoaffinity-labeled functional probe based on prenyl side-chain".chinese journal of organic chemistry 28.3(2008):489-493.