Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells

	Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells
	Cao, Jun ; Jiang, Li-Ping ; Liu, Yong ; Yang, Guang ; Yao, Xiao-Feng ; Zhong, Lai-Fu
刊名	toxicon
	2007-06-15
卷号	49 期号:8 页码:1219-1222
关键词	curcumin genotoxicity antigenotoxicity HepG2 cells cyclophosphamide
英文摘要	curcumin, a polyphenolic yellow pigment found in turmeric, is commonly used as a coloring agent in foods, drugs, and cosmetics. in our previous study, we found that low levels of curcumin did not increase the reactive oxygen species (ros) formation and caused no damage to dna in human hepatoma g2 (hepg2) cells, but at high doses, curcumin imposed oxidative stress and damaged dna. in the present study, we are determined to investigate the genotoxic and antigenotoxic effects of curcumin using hepg2 cell line, a relevant in vitro model to detect the cytoprotective, antigenotoxic, and cogenotoxic agents. the results of micronucleus (mn) assays showed that, on one hand, curcumin at the high tested concentrations (8 and 16 mu g/ml) displayed a small but significant increase in the frequency of mn, and on the other hand, it was observed that the low tested concentration (2 mu g/ml) significantly reduced the mn formation induced by the chemotherapeutic agent cyclophosphamide. the present results indicate that curcumin shows both genotoxicity and anti genotoxicity depending on its concentration. (c) 2007 elsevier ltd. all rights reserved.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	pharmacology & pharmacy ; toxicology
研究领域[WOS]	pharmacology & pharmacy ; toxicology
关键词[WOS]	hamster ovary cells ; induced chromosome-aberrations ; cultured-mammalian-cells ; in-vivo ; damage ; agents ; vitro
收录类别	SCI
语种	英语
WOS记录号	WOS:000247711400018
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/140471]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Dalian Med Univ, Dept Toxicol, Dalian 116027, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Cao, Jun,Jiang, Li-Ping,Liu, Yong,et al. Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells[J]. toxicon,2007,49(8):1219-1222.
APA	Cao, Jun,Jiang, Li-Ping,Liu, Yong,Yang, Guang,Yao, Xiao-Feng,&Zhong, Lai-Fu.(2007).Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells.toxicon,49(8),1219-1222.
MLA	Cao, Jun,et al."Curcumin-induced genotoxicity and antigenotoxicity in HepG2 cells".toxicon 49.8(2007):1219-1222.