Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi

	Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi
	Han, QB ; Yang, L ; Liu, Y ; Wang, YL ; Qiao, CF ; Song, JZ ; Xu, LJ ; Yang, DJ ; Chen, SL ; Xu, HX
刊名	planta medica
	2006-02-01
卷号	72 期号:3 页码:281-284
英文摘要	gambogic acid, usually isolated as an inseparable stereomeric mixture of c-2 epimers, was newly separated into two epimers (1 and 2) from the gamboges of garcinia hanburyi. the stereochemistry at c-2 was clearly defined by extensive spectroscopic analysis and direct comparison of nmr and hplc data with those of the known r-epimer. both epimers were examined for their cytotoxicities against human leukemia k562 (k562/s) and doxorubicin-resistant k562 (k562/r) cell lines. different from doxorubicin (ic50 = 10.78 mu m for k562/r and 0.66 mu m for k562/s), epimers 1 and 2 exhibited similar activities against both cell lines (ic50 = 1.32 and 0.89 mu m for 1, ic50 = 1.11 and 0.86 mu m for 2). these results suggested that both epimers were not multidrug resistance (mdr) substrates. furthermore, epimers 1 and 2 were tested for their inhibitory effects against six human cytochrome p-450 enzymes. epimers 1 and 2 showed little inhibitory effects toward five of the enzymes except cyp2c9. interestingly, when tested against cyp2c9, s-epimer 2 had an inhibitory effect 20-fold stronger than that of r-epimer 1.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	plant sciences ; chemistry, medicinal ; pharmacology & pharmacy
研究领域[WOS]	plant sciences ; pharmacology & pharmacy
关键词[WOS]	in-vitro ; cells ; apoptosis
收录类别	SCI
语种	英语
WOS记录号	WOS:000236279400019
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/140376]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Hong Kong Jockey Club Inst Chinese Med, Chinese Med Lab, Shatin, Hong Kong, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resources Discovery, Dalian, Peoples R China 3.Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Han, QB,Yang, L,Liu, Y,et al. Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi[J]. planta medica,2006,72(3):281-284.
APA	Han, QB.,Yang, L.,Liu, Y.,Wang, YL.,Qiao, CF.,...&Xu, HX.(2006).Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi.planta medica,72(3),281-284.
MLA	Han, QB,et al."Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi".planta medica 72.3(2006):281-284.