Influence of ginsenoside Rh-1 and F-1 on human cytochrome P450 enzymes

	Influence of ginsenoside Rh-1 and F-1 on human cytochrome P450 enzymes
	Liu, Y ; Ma, H ; Zhang, JW ; Deng, MC ; Yang, L
刊名	planta medica
	2006-02-01
卷号	72 期号:2 页码:126-131
关键词	ginsenoside hydrolysis products systemic circulation cytochrome P450
英文摘要	for an oral herbal medicine, the components that can enter the systemic circulation may be the really effective components. in the present study, the effects on the human cytochrome p450 activities of ginsenoside rb-1 and two hydrolysis products of 20(s)protopanaxatriol ginsenosides in humans, namely ginsenoside rb-1 and f-1, which may reach the systemic circulation after oral administration of ginseng extract, were evaluated. our results showed that rb-1 exhibited no marked effects on the activities of human cytochrome p450, whereas rh-1 and f, exhibited competitive inhibition of the activity of cyp3a4 with k-i values of 57.7 +/- 9.6 mu m and 67.8 +/- 16.2 mu m, respectively. f-1 also exhibited a weak- er inhibition of the activity of cyp2d6. rh, exhibited a weak stimulation rather than an inhibition of the activity of cyp2e1. the degradation of ginsenosides in the gastrointestinal tract may play an important role in the ginseng-associated drug-drug interactions, but the effects might be not due to rh-1 and f-1.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	plant sciences ; chemistry, medicinal ; pharmacology & pharmacy
研究领域[WOS]	plant sciences ; pharmacology & pharmacy
关键词[WOS]	herb-drug interactions ; in-vitro ; catalytic-activity ; metabolism ; saponins ; identification ; variability ; absorption ; components ; excretion
收录类别	SCI
语种	英语
WOS记录号	WOS:000235565300005
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/140317]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Sch, Dalian, Peoples R China 3.Liaoning Normal Univ, Coll Life Sci, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Liu, Y,Ma, H,Zhang, JW,et al. Influence of ginsenoside Rh-1 and F-1 on human cytochrome P450 enzymes[J]. planta medica,2006,72(2):126-131.
APA	Liu, Y,Ma, H,Zhang, JW,Deng, MC,&Yang, L.(2006).Influence of ginsenoside Rh-1 and F-1 on human cytochrome P450 enzymes.planta medica,72(2),126-131.
MLA	Liu, Y,et al."Influence of ginsenoside Rh-1 and F-1 on human cytochrome P450 enzymes".planta medica 72.2(2006):126-131.