Highly enantioselective borane reduction of prochiral ketones catalyzed by C-3-symmetric tripodal beta-hydroxy amides

	Highly enantioselective borane reduction of prochiral ketones catalyzed by C-3-symmetric tripodal beta-hydroxy amides
	Fang, Tao; Xu, Jiaxi; Du, Da-Ming
刊名	synlett
	2006-06-11
期号	10 页码:1559-1563
关键词	asymmetric reduction borane ketone beta-hydroxyamide C-3 symmetry
英文摘要	the asymmetric borane reduction of prochiral ketones with a series of easily constructed chiral c-3-symmetric tripodal tris(beta-hydroxyamide) ligands was investigated. the borane complex of chiral ligand 1,1',1"-(1,3,5-benzenetricarbonyl)-tris[(2s)-alpha,alpha-diphenl-2-pyrrolidinemethanol] (1h) was found to be an efficient catalyst in asymmetric borane reduction of prochiral ketones and excellent enantioselectivities were obtained with both electron-deficient and electron-rich prochiral ketones (up to 97% ee).
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, organic
研究领域[WOS]	chemistry
关键词[WOS]	mediated asymmetric reduction ; aromatic ketones ; chiral oxazaborolidines ; amino-alcohols ; reducing agent ; aldehydes ; nabh4/me3sicl ; recognition ; sulfonamide
收录类别	SCI ; IC ; CCR
语种	英语
WOS记录号	WOS:000238732100021
公开日期	2015-11-17
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/140191]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	Peking Univ, Coll Chem & Mol Engn, Key Lab Bioorgan Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Fang, Tao,Xu, Jiaxi,Du, Da-Ming. Highly enantioselective borane reduction of prochiral ketones catalyzed by C-3-symmetric tripodal beta-hydroxy amides[J]. synlett,2006(10):1559-1563.
APA	Fang, Tao,Xu, Jiaxi,&Du, Da-Ming.(2006).Highly enantioselective borane reduction of prochiral ketones catalyzed by C-3-symmetric tripodal beta-hydroxy amides.synlett(10),1559-1563.
MLA	Fang, Tao,et al."Highly enantioselective borane reduction of prochiral ketones catalyzed by C-3-symmetric tripodal beta-hydroxy amides".synlett .10(2006):1559-1563.