Study of urinary nucleosides as biological marker in cancer patients analyzed by micellar electrokinetic capillary chromatography

	Study of urinary nucleosides as biological marker in cancer patients analyzed by micellar electrokinetic capillary chromatography
	Zheng, YF ; Xu, GW ; Liu, DY ; Xiong, JH ; Zhang, PD ; Zhang, C ; Yang, Q ; Lv, S
刊名	electrophoresis
	2002-12-01
卷号	23 期号:24 页码:4104-4109
关键词	cancer micellar electrokinetic capillary chromatography nucleosides principal component analysis tumor markers urine
英文摘要	thirteen normal and modified nucleosides, primarily degradation products of transfer ribonucleic acid (trna), were evaluated as potential tumor markers for cancer patients. their urinary concentrations were determined by means of micellar electrokinetic capillary chromatography (mekc) in the urine from 54 healthy adults and 70 cancer patients, then quantitatively expressed as a function of creatinine excretion. it was found that urinary nucleosides for cancer patients were on the average significantly higher than those for healthy controls, however, no significant differences were found between male and female or between different ages. based on 13 urinary nucleoside concentrations, principal component analysis (pca) could be used to classify 72% of cancer patients from the healthy controls. the present study shows that the precise measurement of urinary nucleosides by mekc in combining with pca technique may provide a clinically useful approach for diagnosis of cancer.
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]	biochemical research methods ; chemistry, analytical
研究领域[WOS]	biochemistry & molecular biology ; chemistry
关键词[WOS]	monoclonal-antibodies ; transfer-rna ; excretion ; electrophoresis ; turnover
收录类别	SCI
语种	英语
WOS记录号	WOS:000180354200008
公开日期	2015-11-10
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/139087]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Natl Chromatog R&A Ctr, Dalian Inst Chem Phys, Dalian 116011, Peoples R China 2.Dalian Med Univ, Dept Pathol, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Zheng, YF,Xu, GW,Liu, DY,et al. Study of urinary nucleosides as biological marker in cancer patients analyzed by micellar electrokinetic capillary chromatography[J]. electrophoresis,2002,23(24):4104-4109.
APA	Zheng, YF.,Xu, GW.,Liu, DY.,Xiong, JH.,Zhang, PD.,...&Lv, S.(2002).Study of urinary nucleosides as biological marker in cancer patients analyzed by micellar electrokinetic capillary chromatography.electrophoresis,23(24),4104-4109.
MLA	Zheng, YF,et al."Study of urinary nucleosides as biological marker in cancer patients analyzed by micellar electrokinetic capillary chromatography".electrophoresis 23.24(2002):4104-4109.