beta-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells

	beta-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells
	Zhao, Yong-Shun 1; Zhu, Ting-Zhun 1; Chen, Yan-Wei 2; Yao, Yi-Qun 1; Wu, Chun-Ming 1; Wei, Zhen-Qing 1; Wang, Wei 3; Xu, Ying-Hui 1
刊名	journal of neuro-oncology
	2012-04-01
卷号	107 期号:2 页码:307-314
关键词	beta-Elemene Hsp90/Raf-1 MAPK Apoptosis Glioblastoma cell
英文摘要	beta-elemene, an active component of herb medicine curcuma wenyujin, has been shown to antagonize glioblastoma cells by inducing apoptosis. however, how beta-elemene induces apoptosis of these cells remains unclear. in this study, we report that beta-elemene disrupted the formation of the hsp90/raf-1 complex, a key step in maintaining the conformation stability of raf-1, and caused deactivation of raf-1 and inhibition of the erk pathway, thereby leading to apoptosis of glioblastoma cells. specifically, treatment of glioblastoma cell lines with beta-elemene attenuated phosphorylation of multiple members of the kinase families in the ras/raf/mek/erk cascade, including raf-1 and erk as well as downstream signaling targets such as bcl-2. these results suggest that the hsp90/raf-1 complex could be a promising molecular target for new drug development for the treatment of glioblastoma.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	oncology ; clinical neurology
研究领域[WOS]	oncology ; neurosciences & neurology
关键词[WOS]	in-vitro ; mitochondria ; pathway ; hsp90 ; raf-1 ; bcl-2 ; erk ; combination ; carcinoma ; survival
收录类别	SCI
语种	英语
WOS记录号	WOS:000303469000010
公开日期	2015-11-10
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/138080]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Dalian Med Univ, Dept Neurosurg, Affiliated Hosp 1, Dalian 116011, Peoples R China 2.Dalian Med Univ, Dept Clin Pharm, Affiliated Hosp 1, Dalian 116011, Peoples R China 3.Chinese Acad Sci, Lab Biomed Mat Engn, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Yong-Shun,Zhu, Ting-Zhun,Chen, Yan-Wei,et al. beta-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells[J]. journal of neuro-oncology,2012,107(2):307-314.
APA	Zhao, Yong-Shun.,Zhu, Ting-Zhun.,Chen, Yan-Wei.,Yao, Yi-Qun.,Wu, Chun-Ming.,...&Xu, Ying-Hui.(2012).beta-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells.journal of neuro-oncology,107(2),307-314.
MLA	Zhao, Yong-Shun,et al."beta-Elemene inhibits Hsp90/Raf-1 molecular complex inducing apoptosis of glioblastoma cells".journal of neuro-oncology 107.2(2012):307-314.