Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro

	Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro
	Yang, Xiaohan 1,2; Xiong, Hai 5; Guan, Zhu-Zhu 1,2; Okai, Isaac 1,2; Ye, Dongmei 1,3; Song, Yang 1,2; Li, Xiao 4; Wang, Lan 1,2; Liu, Lu 1,2; Du, Sha 1,2
刊名	cancer investigation
	2012-07-01
卷号	30 期号:6 页码:453-462
关键词	Small cell lung cancer Caveolin-1 Apoptosis
英文摘要	small cell lung cancer (sclc) is the most aggressive type of lung cancer, and its treatment is closely associated with apoptosis. caveolin-1 plays an important role in the development of a variety of human cancers. this study sought to investigate the influence of caveolin-1 on the apoptosis of sclc in vitro. we demonstrate that higher expression of caveolin-1 leads to inhibition of cisplatin and ultraviolet radiation (uvr)-induced apoptosis in sclc cells; and also could decrease caspase-3 activity and increase the stability of bcl-2 at the protein level. our findings illuminate a potential molecular mechanism regarding cav-1's role as anti-apoptosis protein.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	oncology
研究领域[WOS]	oncology
关键词[WOS]	outer mitochondrial-membrane ; prostate-cancer ; molecular-basis ; bcl-2 ; carcinoma ; receptor ; phase ; stage ; chemotherapy ; metastasis
收录类别	SCI
语种	英语
WOS记录号	WOS:000304751300002
公开日期	2015-11-10
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/138039]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Dalian Med Univ, Dept Histol & Embryol, Dalian 116044, Peoples R China 2.Dalian Med Univ, Liaoning Prov Prote Key Lab, Dalian 116044, Peoples R China 3.Dalian Univ Technol, Dept Anat, Coll Med, Dalian, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 5.Dalian Med Univ, Affiliated Hosp 1, Dept Thorac Surg, Dalian 116044, Peoples R China 6.Chinese Acad Med Sci, Dept Pathol, Beijing 100730, Peoples R China
推荐引用方式 GB/T 7714	Yang, Xiaohan,Xiong, Hai,Guan, Zhu-Zhu,et al. Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro[J]. cancer investigation,2012,30(6):453-462.
APA	Yang, Xiaohan.,Xiong, Hai.,Guan, Zhu-Zhu.,Okai, Isaac.,Ye, Dongmei.,...&Shao, Shujuan.(2012).Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro.cancer investigation,30(6),453-462.
MLA	Yang, Xiaohan,et al."Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro".cancer investigation 30.6(2012):453-462.