Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro | |
Yang, Xiaohan1,2; Xiong, Hai5; Guan, Zhu-Zhu1,2; Okai, Isaac1,2; Ye, Dongmei1,3; Song, Yang1,2; Li, Xiao4; Wang, Lan1,2; Liu, Lu1,2; Du, Sha1,2 | |
刊名 | cancer investigation
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2012-07-01 | |
卷号 | 30期号:6页码:453-462 |
关键词 | Small cell lung cancer Caveolin-1 Apoptosis |
英文摘要 | small cell lung cancer (sclc) is the most aggressive type of lung cancer, and its treatment is closely associated with apoptosis. caveolin-1 plays an important role in the development of a variety of human cancers. this study sought to investigate the influence of caveolin-1 on the apoptosis of sclc in vitro. we demonstrate that higher expression of caveolin-1 leads to inhibition of cisplatin and ultraviolet radiation (uvr)-induced apoptosis in sclc cells; and also could decrease caspase-3 activity and increase the stability of bcl-2 at the protein level. our findings illuminate a potential molecular mechanism regarding cav-1's role as anti-apoptosis protein. |
WOS标题词 | science & technology ; life sciences & biomedicine |
类目[WOS] | oncology |
研究领域[WOS] | oncology |
关键词[WOS] | outer mitochondrial-membrane ; prostate-cancer ; molecular-basis ; bcl-2 ; carcinoma ; receptor ; phase ; stage ; chemotherapy ; metastasis |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000304751300002 |
公开日期 | 2015-11-10 |
内容类型 | 期刊论文 |
源URL | [http://159.226.238.44/handle/321008/138039] ![]() |
专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
作者单位 | 1.Dalian Med Univ, Dept Histol & Embryol, Dalian 116044, Peoples R China 2.Dalian Med Univ, Liaoning Prov Prote Key Lab, Dalian 116044, Peoples R China 3.Dalian Univ Technol, Dept Anat, Coll Med, Dalian, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 5.Dalian Med Univ, Affiliated Hosp 1, Dept Thorac Surg, Dalian 116044, Peoples R China 6.Chinese Acad Med Sci, Dept Pathol, Beijing 100730, Peoples R China |
推荐引用方式 GB/T 7714 | Yang, Xiaohan,Xiong, Hai,Guan, Zhu-Zhu,et al. Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro[J]. cancer investigation,2012,30(6):453-462. |
APA | Yang, Xiaohan.,Xiong, Hai.,Guan, Zhu-Zhu.,Okai, Isaac.,Ye, Dongmei.,...&Shao, Shujuan.(2012).Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro.cancer investigation,30(6),453-462. |
MLA | Yang, Xiaohan,et al."Higher Expression of Caveolin-1 Inhibits Human Small Cell Lung Cancer (SCLC) Apoptosis In Vitro".cancer investigation 30.6(2012):453-462. |
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