Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis

	Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis
	Zheng, Wei 1,2; Luo, Qun 1,2; Lin, Yu 1,2; Zhao, Yao 1,2; Wang, Xiuli 3; Du, Zhifeng 1,2; Hao, Xiang 1; Yu, Yang 3; Lu, Shuang 1,2; Ji, Liyun 1,2
刊名	chemical communications
	2013
卷号	49 期号:87 页码:10224-10226
英文摘要	the complexation with organoruthenium fragments confers 4-anilinoquinazoline pharmacophores with higher potential for inducing cellular apoptosis while the highly inhibitory activity of 4-anilinoquinazolines against egfr and the reactivity of the ruthenium centre to 9-ethylguanine are well preserved.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, multidisciplinary
研究领域[WOS]	chemistry
关键词[WOS]	post-genomic era ; arene complexes ; in-vitro ; kinase inhibitors ; cell cytotoxicity ; antitumor drugs ; metal-complexes ; chemical space ; cancer-cells ; binding
收录类别	SCI
语种	英语
WOS记录号	WOS:000325643500004
公开日期	2015-11-10
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/137627]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Chem, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Wei,Luo, Qun,Lin, Yu,et al. Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis[J]. chemical communications,2013,49(87):10224-10226.
APA	Zheng, Wei.,Luo, Qun.,Lin, Yu.,Zhao, Yao.,Wang, Xiuli.,...&Wang, Fuyi.(2013).Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis.chemical communications,49(87),10224-10226.
MLA	Zheng, Wei,et al."Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis".chemical communications 49.87(2013):10224-10226.