DNA Catalyzed Dithioacetalization in Water

	DNA Catalyzed Dithioacetalization in Water
	Wang Changhao; Li Yinghao; Jia Guoqing; Lu Shengmei; Liu Yan; Li Can
刊名	acta chimica sinica
	2013-01-15
卷号	71 期号:1 页码:36-39
关键词	double-stranded DNA herring sperm catalysis dithioacetalization water medium phosphate group
英文摘要	the most popular hypothesis of precellular life is the "rna world", which is utilizing rna as both genetic as well as catalytic material. the chemical similarity between rna and dna leads researchers to investigate whether dna has the catalytic function, although dna is commonly viewed as a genetic carrier with a ubiquitous double-stranded architecture in living world. nevertheless, the catalytic dna has not been discovered in nature to date. in recent years, the catalytic function of dna in nonbiological applications has aroused much interest to chemists in chemical synthesis such as dna-templated organic synthesis and dna-based asymmetric catalysis. however, the investigation of dna as a direct catalyst for organic synthesis is largely elusive. here we report that double-stranded dna from herring sperm can catalyze the dithioacetalization in water for a wide range of aldehydes under mild reaction conditions. it is proposed that the phosphate groups of dna together with the duplex architecture are responsible for the catalytic reaction.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, multidisciplinary
研究领域[WOS]	chemistry
关键词[WOS]	chemoselective dithioacetalization ; carbonyl-compounds ; organic-synthesis ; efficient catalyst ; aldol reaction ; aqueous-media ; rna world ; acid ; thioacetalization ; aldehydes
收录类别	SCI ; CCR
语种	英语
WOS记录号	WOS:000315605300003
公开日期	2015-11-10
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/137473]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Wang Changhao,Li Yinghao,Jia Guoqing,et al. DNA Catalyzed Dithioacetalization in Water[J]. acta chimica sinica,2013,71(1):36-39.
APA	Wang Changhao,Li Yinghao,Jia Guoqing,Lu Shengmei,Liu Yan,&Li Can.(2013).DNA Catalyzed Dithioacetalization in Water.acta chimica sinica,71(1),36-39.
MLA	Wang Changhao,et al."DNA Catalyzed Dithioacetalization in Water".acta chimica sinica 71.1(2013):36-39.