Functionalization of DNA-Dendron Supramolecular Fibers and Application in Regulation of Escherichia coli Association

	Functionalization of DNA-Dendron Supramolecular Fibers and Application in Regulation of Escherichia coli Association
	Wu, Fen 1; Jin, Juan 2; Wang, Liying 1; Sun, Pengfei 3,4; Yuan, Huanxiang 5; Yang, Zhongqiang 2; Chen, Guosong 3,4; Fan, Qing-Hua 1; Liu, Dongsheng 2
刊名	ACS APPLIED MATERIALS & INTERFACES
	2015-04-08
卷号	7 期号:13 页码:7351-7356
关键词	carbohydrate recognition DNA self-assembly multivalent scaffolds E. coli association and dissociation
英文摘要	Specific carbohydrate recognition in biology is a dynamic process. Thus, supramolecular multivalent scaffolds with dynamic features have been applied to mimic this process. Herein, we prepared DNA-dendron supramolecular fibers and synthesized carbohydrate-oligonucleotide conjugates (C18-mannose). Via DNA hybridization, the C18-mannose could be guided onto the fiber platform and form multiple mannose-functionalized fibers, which can be utilized to agglutinate E. coli because of high affinity among multivalent mannose ligands and receptors on E. coli. In addition, via chain exchange reaction of DNAs, the E. coli could be dissociated by replacing multivalent mannose ligands with competitive unmodified DNA sequences. The association and dissociation processes of E. coli are confirmed by fluorescent microscope and transmission electron microscope (TEM). These results not only demonstrate the ability of DNA-dendron fibers in reversibly associating E. coli but also illustrate their potential to be an easily modified multivalent supramolecular platform.
收录类别	SCI
语种	英语
公开日期	2015-11-03
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/28537]
专题	化学研究所_分子识别与功能实验室
作者单位	1.Chinese Acad Sci, CAS Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China 2.Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Organ Optoelect & Mol Engn, Beijing 100084, Peoples R China 3.Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China 4.Fudan Univ, Dept Macromol Sci, Shanghai 200433, Peoples R China 5.Chinese Acad Sci, Beijing Natl Lab Mol Sci BNLMS, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wu, Fen,Jin, Juan,Wang, Liying,et al. Functionalization of DNA-Dendron Supramolecular Fibers and Application in Regulation of Escherichia coli Association[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(13):7351-7356.
APA	Wu, Fen.,Jin, Juan.,Wang, Liying.,Sun, Pengfei.,Yuan, Huanxiang.,...&Liu, Dongsheng.(2015).Functionalization of DNA-Dendron Supramolecular Fibers and Application in Regulation of Escherichia coli Association.ACS APPLIED MATERIALS & INTERFACES,7(13),7351-7356.
MLA	Wu, Fen,et al."Functionalization of DNA-Dendron Supramolecular Fibers and Application in Regulation of Escherichia coli Association".ACS APPLIED MATERIALS & INTERFACES 7.13(2015):7351-7356.