Cinchona alkaloid thiourea mediated asymmetric Mannich reaction of isocyanoacetates with isatin-derived ketimines and subsequent cyclization: enantioselective synthesis of spirooxindole imidazolines

	Cinchona alkaloid thiourea mediated asymmetric Mannich reaction of isocyanoacetates with isatin-derived ketimines and subsequent cyclization: enantioselective synthesis of spirooxindole imidazolines
	Zhao, Mei-Xin 1,2,3; Jing, Lei 1,2; Zhou, Hao 1,2; Shi, Min 1,2,4
刊名	RSC ADVANCES
	2015
卷号	5 期号:92 页码:75648-75652
英文摘要	We report the organocatalyzed asymmetric Mannich reaction of isocyanoacetates with isatin derived ketimines in good yields along with high stereoselectivities. The subsequent organocatalyzed cyclization of Mannich adducts is also investigated, emerging as a promising strategy for the synthesis of optically active spirooxindole imidazolines.
收录类别	SCI
语种	英语
公开日期	2015-11-03
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/28395]
专题	化学研究所_分子识别与功能实验室
作者单位	1.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China 2.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Mei-Xin,Jing, Lei,Zhou, Hao,et al. Cinchona alkaloid thiourea mediated asymmetric Mannich reaction of isocyanoacetates with isatin-derived ketimines and subsequent cyclization: enantioselective synthesis of spirooxindole imidazolines[J]. RSC ADVANCES,2015,5(92):75648-75652.
APA	Zhao, Mei-Xin,Jing, Lei,Zhou, Hao,&Shi, Min.(2015).Cinchona alkaloid thiourea mediated asymmetric Mannich reaction of isocyanoacetates with isatin-derived ketimines and subsequent cyclization: enantioselective synthesis of spirooxindole imidazolines.RSC ADVANCES,5(92),75648-75652.
MLA	Zhao, Mei-Xin,et al."Cinchona alkaloid thiourea mediated asymmetric Mannich reaction of isocyanoacetates with isatin-derived ketimines and subsequent cyclization: enantioselective synthesis of spirooxindole imidazolines".RSC ADVANCES 5.92(2015):75648-75652.