G-quadruplex induced chirality of methylazacalix[6]pyridine via unprecedented binding stoichiometry: en route to multiplex controlled molecular switch

CORC > 化学研究所 > 中国科学院化学研究所 > 分子动态与稳态结构实验室

	G-quadruplex induced chirality of methylazacalix[6]pyridine via unprecedented binding stoichiometry: en route to multiplex controlled molecular switch
	Guan, Ai-Jiao 1; Shen, Meng-Jie 2; Xiang, Jun-Feng 1; Zhang, En-Xuan 1; Li, Qian 1; Sun, Hong-Xia 1; Wang, Li-Xia 1; Xu, Guang-Zhi 1; Tang, Ya-Lin 1; Xu, Li-Jin 2
刊名	SCIENTIFIC REPORTS
	2015-05-20
卷号	5
英文摘要	Nucleic acid based molecular device is a developing research field which attracts great interests in material for building machinelike nanodevices. G-quadruplex, as a new type of DNA secondary structures, can be harnessed to construct molecular device owing to its rich structural polymorphism. Herein, we developed a switching system based on G-quadruplexes and methylazacalix[6]pyridine (MACP6). The induced circular dichroism (CD) signal of MACP6 was used to monitor the switch controlled by temperature or pH value. Furthermore, the CD titration, Job-plot, variable temperature CD and H-1-NMR experiments not only confirmed the binding mode between MACP6 and G-quadruplex, but also explained the difference switching effect of MACP6 and various G-quadruplexes. The established strategy has the potential to be used as the chiral probe for specific G-quadruplex recognition.
收录类别	SCI
语种	英语
公开日期	2015-11-02
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/28114]
专题	化学研究所_分子动态与稳态结构实验室
作者单位	1.Chinese Acad Sci, Ctr Mol Sci, Inst Chem,Beijing Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China 2.Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China 3.Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China
推荐引用方式 GB/T 7714	Guan, Ai-Jiao,Shen, Meng-Jie,Xiang, Jun-Feng,et al. G-quadruplex induced chirality of methylazacalix[6]pyridine via unprecedented binding stoichiometry: en route to multiplex controlled molecular switch[J]. SCIENTIFIC REPORTS,2015,5.
APA	Guan, Ai-Jiao.,Shen, Meng-Jie.,Xiang, Jun-Feng.,Zhang, En-Xuan.,Li, Qian.,...&Gong, Han-Yuan.(2015).G-quadruplex induced chirality of methylazacalix[6]pyridine via unprecedented binding stoichiometry: en route to multiplex controlled molecular switch.SCIENTIFIC REPORTS,5.
MLA	Guan, Ai-Jiao,et al."G-quadruplex induced chirality of methylazacalix[6]pyridine via unprecedented binding stoichiometry: en route to multiplex controlled molecular switch".SCIENTIFIC REPORTS 5(2015).