Recognizing parallel-stranded G-quadruplex by cyanine dye dimer based on dual-site binding mode

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	Recognizing parallel-stranded G-quadruplex by cyanine dye dimer based on dual-site binding mode
	Yu, Li-Jia 1,2; Gai, Wei 1,2; Yang, Qian-Fan 1; Xiang, Jun-Feng 1; Sun, Hong-Xia 1; Li, Qian 1; Wang, Li-Xia 1; Guan, Ai-Jiao 1; Tang, Ya-Lin 1
刊名	CHINESE CHEMICAL LETTERS
	2015-06-01
卷号	26 期号:6 页码:705-708
关键词	Parallel-stranded G-quadruplex Cyanine dye Dual-site binding mode c-myc
英文摘要	G-quadruplexes (G4s) play important roles in biological systems, such as telomere maintenance, replication, and transcription. Based on the DNA sequence, loop geometry, and the local environments, G4s can be classified into different conformations. It is important to detect different types of G4s to monitor the diseases related with G4s. Most ligands bind to G4s based on end-stacking modes, while rare ligands bind to G4s through groove binding modes. We have found that a cyanine dye DMSB interacts with parallel G4 by end-stacking and groove simultaneous binding mode. In this article, we found that DMSB could simply discriminate parallel G4s from other DNA motifs by using UV-vis spectrum. These results give some clues to develop high specificity G4 probes. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
收录类别	SCI
语种	英语
公开日期	2015-11-02
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/27912]
专题	化学研究所_分子动态与稳态结构实验室
作者单位	1.Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & State Specie, Beijing Natl Lab Mol Sci,Ctr Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yu, Li-Jia,Gai, Wei,Yang, Qian-Fan,et al. Recognizing parallel-stranded G-quadruplex by cyanine dye dimer based on dual-site binding mode[J]. CHINESE CHEMICAL LETTERS,2015,26(6):705-708.
APA	Yu, Li-Jia.,Gai, Wei.,Yang, Qian-Fan.,Xiang, Jun-Feng.,Sun, Hong-Xia.,...&Tang, Ya-Lin.(2015).Recognizing parallel-stranded G-quadruplex by cyanine dye dimer based on dual-site binding mode.CHINESE CHEMICAL LETTERS,26(6),705-708.
MLA	Yu, Li-Jia,et al."Recognizing parallel-stranded G-quadruplex by cyanine dye dimer based on dual-site binding mode".CHINESE CHEMICAL LETTERS 26.6(2015):705-708.