EFFECT OF ACARBOSE ON CONTENT OF URINARY ENDOGENOUS METABOLITES OF DIABETIC RATS

	EFFECT OF ACARBOSE ON CONTENT OF URINARY ENDOGENOUS METABOLITES OF DIABETIC RATS
	Pi, Zifeng ; Jiang, Hongyu ; Zhang, Jing ; Tao,Li ; Song,Fengrui ; Liu,Zhiqing
刊名	journal of liquid chromatography & related technologies
	2014
卷号	37 期号:17 页码:2478-2489
关键词	MELLITUS SPECTROMETRY METABONOMICS DIAGNOSIS SERUM NMR
通讯作者	jiang,hy
英文摘要	four kinds of endogenous metabolites, including creatinine, phenylacetylglycine, hippuric acid, and gluconic acid, were as potential biomarkers by a urinary metabolomics method in our previous study. to confirm them and investigate the effect of acarbose on type 2 diabetes in rats, a sensitive and selective ultra performance liquid chromatography tandem mass spectrometry (uplc-ms/ms) method was developed to determine the concentration of the four kinds of endogenous metabolites in the urine of diabetes rats between pre- and post-treatment by acarbose. the results showed that the four kinds of endogenous metabolites were authenticated as the urinary biomarker of the diabetes rats. but after treating with acarbose, the content of phenylacetylglycine was significantly decreased in the urine of diabetic rats, while the content of other three kinds of endogenous metabolites did not change significantly. this means that phenylacetylglycine related intestinal bacteria metabolic pathway probably was the major pathway during the treatment of acarbose and the effect on other metabolic pathways related to creatinine, hippuric acid, and gluconic acid metabolites was relatively weak.
收录类别	SCI
语种	英语
公开日期	2015-10-27
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/57567]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Pi, Zifeng,Jiang, Hongyu,Zhang, Jing,et al. EFFECT OF ACARBOSE ON CONTENT OF URINARY ENDOGENOUS METABOLITES OF DIABETIC RATS[J]. journal of liquid chromatography & related technologies,2014,37(17):2478-2489.
APA	Pi, Zifeng,Jiang, Hongyu,Zhang, Jing,Tao,Li,Song,Fengrui,&Liu,Zhiqing.(2014).EFFECT OF ACARBOSE ON CONTENT OF URINARY ENDOGENOUS METABOLITES OF DIABETIC RATS.journal of liquid chromatography & related technologies,37(17),2478-2489.
MLA	Pi, Zifeng,et al."EFFECT OF ACARBOSE ON CONTENT OF URINARY ENDOGENOUS METABOLITES OF DIABETIC RATS".journal of liquid chromatography & related technologies 37.17(2014):2478-2489.