Efficient side-chain modification of dextran via base-catalyzed epoxide ring-opening and thiol-ene click chemistry in aqueous media

	Efficient side-chain modification of dextran via base-catalyzed epoxide ring-opening and thiol-ene click chemistry in aqueous media
	Li, Ming-qiang ; Tang, Zhao-hui ; Wang, Chao ; Zhang,Yu ; Cui,Hai-tao ; Chen,Xue-si
刊名	高分子科学(英文版) chinese journal of polymer science
	2014
卷号	32 期号:8 页码:969-974
关键词	IRON-OXIDE NANOPARTICLES CANCER-THERAPY GENE DELIVERY DOXORUBICIN HYDROGELS THERAPEUTICS CISPLATIN PLATFORM RELEASE SYSTEM
通讯作者	chen,xs
英文摘要	in this study, a novel approach by combining base-catalyzed epoxide ring-opening and thiol-ene click chemistry is presented for the side-chain modification of dextran. the vinyl-modified dextran is prepared by a basic epoxide ring opening reaction of allyl glycidyl ether in 0.1 mol/l naoh, followed by thiol-addition click reaction of three model sulfhydryl compounds using water-soluble irgacure 2959 as the photoinitiator, leading to side-chain functionalized dextran modified with carboxyl, bidentate dicarboxyl or amino groups. this is the first example of combining epoxide ring-opening and thiolene click chemistry for side-chain modification of dextran in aqueous media. importantly, it may also be extended as a convenient and efficient method for the side-chain modification of other polysaccharides.
收录类别	SCI
语种	英语
公开日期	2015-10-27
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/57467]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Li, Ming-qiang,Tang, Zhao-hui,Wang, Chao,et al. Efficient side-chain modification of dextran via base-catalyzed epoxide ring-opening and thiol-ene click chemistry in aqueous media[J]. 高分子科学(英文版) chinese journal of polymer science,2014,32(8):969-974.
APA	Li, Ming-qiang,Tang, Zhao-hui,Wang, Chao,Zhang,Yu,Cui,Hai-tao,&Chen,Xue-si.(2014).Efficient side-chain modification of dextran via base-catalyzed epoxide ring-opening and thiol-ene click chemistry in aqueous media.高分子科学(英文版) chinese journal of polymer science,32(8),969-974.
MLA	Li, Ming-qiang,et al."Efficient side-chain modification of dextran via base-catalyzed epoxide ring-opening and thiol-ene click chemistry in aqueous media".高分子科学(英文版) chinese journal of polymer science 32.8(2014):969-974.