Effect of polyelectrolyte adsorption on lateral distribution and dynamics of anionic lipids: a Monte Carlo study of a coarse-grain model

	Effect of polyelectrolyte adsorption on lateral distribution and dynamics of anionic lipids: a Monte Carlo study of a coarse-grain model
	Duan, Xiaozheng ; Zhang, Ran ; Li, Yunqi ; Yang,Yongbiao ; Shik,Tongfei ; An,Lijia ; Huang,Qingrong
刊名	european biophysics journal with biophysics letters
	2014
卷号	43 期号:8-9 页码:377-391
关键词	PHOSPHATIDYLINOSITOL 4 PLASMA-MEMBRANE ORDERED MEDIA ELECTROSTATIC INTERACTIONS SURFACE-CHARGE PROTEIN LOCALIZATION BASIC PEPTIDES MACROMOLECULES BINDING PIP2 5-BISPHOSPHATE
通讯作者	shi,tf
英文摘要	we employ monte carlo simulations to investigate the interaction between an adsorbing linear flexible cationic polyelectrolyte and a ternary mixed fluid membrane containing neutral (phosphatidylcholine, pc), monovalent (phosphatidylserine, ps), and multivalent (phosphatidylinositol, pip2) anionic lipids. we systematically explore the influences of polyelectrolyte chain length, polyelectrolyte charge density, polyelectrolyte total charge amount, and salt solution ionic strength on the static and dynamic properties of different anionic lipid species. our results show that the multivalent pip2 lipids dominate the polyelectrolyte-membrane interaction and competitively inhibit polyelectrolyte-ps binding. when the total charge amount of the polyelectrolyte is less than that of the local oppositely charged pip2 lipids, the polyelectrolyte can drag the bound multivalent lipids to diffuse on the membrane, but cannot interact with the ps lipids. under this condition, the diffusion behaviors of the polyelectrolyte closely follow the prediction of the rouse model, and the polyelectrolyte chain properties determine the adsorption amount, concentration gradients, and hierarchical mobility of the bound pip2 lipids. however, when the total charge amount of the polyelectrolyte is larger than that of the local pip2 lipids, the polyelectrolyte further binds the ps lipids around the polyelectrolyte-pip2 complex to achieve local electrical neutrality. in this condition, parts of the polyelectrolyte desorb from the membrane and show faster mobility, and the bound ps presents much faster mobility than the segregated pip2. this work provides an explanation for heterogeneity formation in different anionic lipids induced by polyelectrolyte adsorption.
收录类别	SCI
语种	英语
WOS记录号	WOS:000340538400004
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/57431]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Duan, Xiaozheng,Zhang, Ran,Li, Yunqi,et al. Effect of polyelectrolyte adsorption on lateral distribution and dynamics of anionic lipids: a Monte Carlo study of a coarse-grain model[J]. european biophysics journal with biophysics letters,2014,43(8-9):377-391.
APA	Duan, Xiaozheng.,Zhang, Ran.,Li, Yunqi.,Yang,Yongbiao.,Shik,Tongfei.,...&Huang,Qingrong.(2014).Effect of polyelectrolyte adsorption on lateral distribution and dynamics of anionic lipids: a Monte Carlo study of a coarse-grain model.european biophysics journal with biophysics letters,43(8-9),377-391.
MLA	Duan, Xiaozheng,et al."Effect of polyelectrolyte adsorption on lateral distribution and dynamics of anionic lipids: a Monte Carlo study of a coarse-grain model".european biophysics journal with biophysics letters 43.8-9(2014):377-391.