Multifunctional AS1411-functionalized fluorescent gold nanoparticles for targeted cancer cell imaging and efficient photodynamic therapy

	Multifunctional AS1411-functionalized fluorescent gold nanoparticles for targeted cancer cell imaging and efficient photodynamic therapy
	Ai, Jun ; Xu, Yuanhong ; Lou, Baohua ; Li,Dan ; Wang,Erkang
刊名	talanta
	2014
卷号	118 期号:1 页码:54-60
关键词	G-QUADRUPLEX PROTOPORPHYRIN-IX DRUG-DELIVERY APTAMER PROBE PROTEIN SIZE ION
通讯作者	wang,ek
英文摘要	herein, one multifunctional as1411-functionalized fluorescent gold nanoparticles (named naanps) is synthesized and successfully applied for both targeted cancer cell imaging and efficient photodynamic therapy (pdt). the naanps are obtained by functionalizing the gold nanoparticles with as1411 aptamer and then bound with one porphyrin derivative n-methylmesoporphyrin ix (nmm). using hela cells over expressing nucleolin as representative cancer cells, the formed naanps can target to the cell surface via the specific as1411-nucleolin interaction, which can discriminate the cancer cells from normal ones (e.g. hek293) unambiguously. that the fluorescence intensity of nmm increased significantly upon binding to as1411 g-quadruplex makes the naanps appropriate fluorescence reagent for cell imaging. meanwhile, nmm can also be used as a photosensitizer, thus irradiation of the naanps by the white light from a common electric torch can lead to efficient production of cytotoxic reactive oxygen species for establishing a new type of pdt to cancer cells. gold nanoparticles play the roles of both carrier and enhancer of the functional groups onto the cells. in addition, they not only possess inherently certain cytotoxicity to the cancer cells, but also boost the cellular uptake of the fluorescent groups. as a result, the efficiency of both the targeted cell imaging and pdt could be ensured. (c) 2013 elsevier b.v. all rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000329553600008
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/57323]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Ai, Jun,Xu, Yuanhong,Lou, Baohua,et al. Multifunctional AS1411-functionalized fluorescent gold nanoparticles for targeted cancer cell imaging and efficient photodynamic therapy[J]. talanta,2014,118(1):54-60.
APA	Ai, Jun,Xu, Yuanhong,Lou, Baohua,Li,Dan,&Wang,Erkang.(2014).Multifunctional AS1411-functionalized fluorescent gold nanoparticles for targeted cancer cell imaging and efficient photodynamic therapy.talanta,118(1),54-60.
MLA	Ai, Jun,et al."Multifunctional AS1411-functionalized fluorescent gold nanoparticles for targeted cancer cell imaging and efficient photodynamic therapy".talanta 118.1(2014):54-60.