Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier

	Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier
	Guo,Zhaopei ; Tian,Huayu ; Lin,Lin ; Chen,Jie ; He,Chaoliang ; Tang,Zhaohui ; Chen,Xuesi
刊名	macromolecular bioscience
	2014
卷号	14 期号:10 页码:1406-1414
关键词	GENE DELIVERY VECTORS GLYCOL) COPOLYMERS BUFFERING CAPACITY CANCER-THERAPY DNA DELIVERY PEI POLY(GLYCOAMIDOAMINE)S NANOPARTICLES TRANSFECTION PBLG
通讯作者	tian,hy
英文摘要	successful gene therapy for cancer treatment and various human genetic diseases relies on high efficient gene carriers, and many carriers can efficiently deliver plasmid dna to cells, while most of them are unefficient in sirna delivery. in this study, a series of amphiphilic copolymers are synthesized for pdna and sirna delivery by grafting hydrophobic polyalanine to polyethylenimine (named ppas). there are 12.5, 7.2, 12.3 and 11.3 times of gene expression more than pei in hela, 293t, a549 and cho cell lines for the optimal ppas, and the highest luciferase knockdown efficiency in huh7 and ct26 cells are investigated to be 90.4% and 89.0%, respectively. this meant the ppas have the potential as efficient transfection reagents for pdna and sirna delivery in future gene therapy.
收录类别	SCI
语种	英语
公开日期	2015-10-27
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/57243]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Guo,Zhaopei,Tian,Huayu,Lin,Lin,et al. Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier[J]. macromolecular bioscience,2014,14(10):1406-1414.
APA	Guo,Zhaopei.,Tian,Huayu.,Lin,Lin.,Chen,Jie.,He,Chaoliang.,...&Chen,Xuesi.(2014).Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier.macromolecular bioscience,14(10),1406-1414.
MLA	Guo,Zhaopei,et al."Hydrophobic Polyalanine Modified Hyperbranched Polyethylenimine as High Efficient pDNA and siRNA Carrier".macromolecular bioscience 14.10(2014):1406-1414.