LHRH-peptide conjugated dextran nanoparticles for targeted delivery of cisplatin to breast cancer

	LHRH-peptide conjugated dextran nanoparticles for targeted delivery of cisplatin to breast cancer
	Li, Mingqiang ; Tang, Zhaohui ; Zhang, Yu ; Lv,Shixian ; Yu,Haiyang ; Zhang,Dawei ; Hong,Hua ; Chen,Xuesi
刊名	journal of materials chemistry b
	2014
卷号	2 期号:22 页码:3490-3499
关键词	INTRACELLULAR DRUG-DELIVERY INCORPORATED POLYMERIC MICELLES IN-VIVO PERFORMANCE BIODEGRADABLE POLYMER ANTITUMOR-ACTIVITY SOLID TUMORS LUNG-CANCER DOXORUBICIN CELLS LIPOSOMES
通讯作者	chen,xs
英文摘要	cisplatin is one of the most common anticancer agents for treating different kinds of solid tumors today. however, its broader therapeutic applications are limited by the severe side effects and nonspecific biodistribution. in this study, luteinizing hormone-releasing hormone (lhrh)-targeted polysaccharide nanoparticles for tumor-targeted delivery and controlled release of cisplatin were developed. this nanoparticle delivery system possessed the following unique properties: (1) as the degradation products of the carrier, both dextran and succinic acid have been proved by the united states food and drug administration for parenteral use, indicating good safety and great application potential; (2) both the drug loading and lhrh conjugation procedures were carried out with efficiency in aqueous medium without the use of organic solvents, thus representing a green chemistry approach; and (3) the design followed the principle of drug encapsulation first and subsequent targeting ligand modification, guaranteeing that the targeting molecules were conjugated on the surface of nanoparticles. as compared to free cisplatin, both the non-targeted and targeted nanoparticles displayed sustained drug release, prolonged blood circulation and reduced systemic toxicity. foremost, the lhrh-targeted nanoparticles led to significant higher cellular internalization in mcf-7 tumor cells in vitro and enhanced accumulation in mcf-7 xenograft tumors in vivo, compared with the non-targeted counterparts. systemic delivery of the targeted nanoparticles carrying cisplatin via intravenous injection showed enhanced tumor suppression in mcf-7 tumor bearing mice compared to the non-targeted nanoparticles and free cddp. collectively, the lhrh-mediated polysaccharide nanoparticles appeared to be a promising nanomedicine drug delivery system for tumor-targeted delivery of cisplatin.
收录类别	SCI
语种	英语
公开日期	2015-10-27
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/56218]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Li, Mingqiang,Tang, Zhaohui,Zhang, Yu,et al. LHRH-peptide conjugated dextran nanoparticles for targeted delivery of cisplatin to breast cancer[J]. journal of materials chemistry b,2014,2(22):3490-3499.
APA	Li, Mingqiang.,Tang, Zhaohui.,Zhang, Yu.,Lv,Shixian.,Yu,Haiyang.,...&Chen,Xuesi.(2014).LHRH-peptide conjugated dextran nanoparticles for targeted delivery of cisplatin to breast cancer.journal of materials chemistry b,2(22),3490-3499.
MLA	Li, Mingqiang,et al."LHRH-peptide conjugated dextran nanoparticles for targeted delivery of cisplatin to breast cancer".journal of materials chemistry b 2.22(2014):3490-3499.