Perylene derivative-bridged Au-graphene nanohybrid for label-free HpDNA biosensor

	Perylene derivative-bridged Au-graphene nanohybrid for label-free HpDNA biosensor
	Zhang, Wei ; Li, Fenghua ; Hu, Yuwei ; Gan,Shiyu ; Han,Dongxue ; Zhang,Qixian ; Niu,Li
刊名	journal of materials chemistry b
	2014
卷号	2 期号:20 页码:3142-3148
关键词	MOLECULAR BEACON BIOSENSORS DNA HYBRIDIZATION CARBON NANOTUBES OXIDE NANOPARTICLES SHEETS PROBE COMPOSITES SURFACTANT NANOSHEETS
通讯作者	niu,l
英文摘要	along with the challenges of wet-chemically preparing graphene-based nanohybrids, for example easy aggregation, low-stability in solution environment and insufficient loading amount, here we report the preparation and application of a type of p-conjugated molecule, perylenetetracarboxylic acid di-imide (pdi)-functionalized graphene material with high density of gold nanoparticles (aunps). in this nanohybrid, the pdi molecule comprises five-connected benzene rings and positively charged terminals composed of two symmetrical imidazole rings and amine groups, which offers the intrinsic driving force for p-p interactions with graphene and also serves as the active sites for immobilization of aunps. transmission electron microscopy results demonstrated that aunps were uniformly dispersed and densely covered the pdi-functionalized graphene compared to the control experiment without pdi. to prove its biological application, the au-pdi-graphene nanohybrid was chosen as a sensing material for fabricating a label-free electrochemical impedance hairpin dna (hpdna) biosensor for detection of human immunodeficiency virus 1 gene. when hpdna was hybridized, it exhibited a sensitive electrochemical impedance variation on an au-pdi-graphene modified electrode. this fabricated hpdna biosensor reveals a wide linear detection range and a relatively low detection limit. thanks to its high stability and efficient electrochemical impedance sensitivity, this nanohybrid would offer a broad range of possible dna sequences for specific applications in biodiagnostics and bionanotechnology.
收录类别	SCI
语种	英语
WOS记录号	WOS:000335225400020
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/56217]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhang, Wei,Li, Fenghua,Hu, Yuwei,et al. Perylene derivative-bridged Au-graphene nanohybrid for label-free HpDNA biosensor[J]. journal of materials chemistry b,2014,2(20):3142-3148.
APA	Zhang, Wei.,Li, Fenghua.,Hu, Yuwei.,Gan,Shiyu.,Han,Dongxue.,...&Niu,Li.(2014).Perylene derivative-bridged Au-graphene nanohybrid for label-free HpDNA biosensor.journal of materials chemistry b,2(20),3142-3148.
MLA	Zhang, Wei,et al."Perylene derivative-bridged Au-graphene nanohybrid for label-free HpDNA biosensor".journal of materials chemistry b 2.20(2014):3142-3148.