Separating human serums of health and hyperlipidaemia subjects using diffusion-weighted nuclear magnetic resonance spectroscopy

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Separating human serums of health and hyperlipidaemia subjects using diffusion-weighted nuclear magnetic resonance spectroscopy
	Lan Wen-Xian; Zhu Hang; Liu Mai-Li
刊名	CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
	2008-07-01
卷号	36 期号:7 页码:935-940
关键词	nuclear magnetic resonance diffusion-weighted nuclear magnetic resonce (NMR) coronary heart disease principal component analysis
英文摘要	It is demonstrated that combination of diffusion-weighted NMR spectroscopy and principle components analysis (PCA) can be used to discriminate serums of patients with coronary heart disease (CHD) from that of health subjects. Diffusion-weighted H-1 NMR spectroscopy is a powerful approach for enhancing resonances from large molecules and suppressing resonances of low molecular-weight metabolites without disturbing physiological properties of human serum samples. The best diffusion weighting factor is found to be around b = 0.85 x 10(7) s/cm(2), increasing or decreasing the diffusion weighting factor destructs the discrimination efficiency. These preliminary results show that high density and low density lipoproteins (HDL & LDL) are the key components contributed to the discrimination, while very small metabolites (such as lactate etc.) and larger lipoproteins (such as very lower density lipoproteins, very low density lipoproteins (VLDL etc. have less effects.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Analytical
研究领域[WOS]	Chemistry
关键词[WOS]	PRINCIPAL COMPONENT ANALYSIS ; HUMAN BLOOD-PLASMA ; NMR-SPECTROSCOPY ; LIPOPROTEINS ; COEFFICIENTS
收录类别	SCI
语种	英语
WOS记录号	WOS:000258939700014
公开日期	2015-10-13
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/8079]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
推荐引用方式 GB/T 7714	Lan Wen-Xian,Zhu Hang,Liu Mai-Li. Separating human serums of health and hyperlipidaemia subjects using diffusion-weighted nuclear magnetic resonance spectroscopy[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2008,36(7):935-940.
APA	Lan Wen-Xian,Zhu Hang,&Liu Mai-Li.(2008).Separating human serums of health and hyperlipidaemia subjects using diffusion-weighted nuclear magnetic resonance spectroscopy.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,36(7),935-940.
MLA	Lan Wen-Xian,et al."Separating human serums of health and hyperlipidaemia subjects using diffusion-weighted nuclear magnetic resonance spectroscopy".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 36.7(2008):935-940.