Separating human serums of health and hyperlipidaemia subjects using diffusion-weighted nuclear magnetic resonance spectroscopy | |
Lan Wen-Xian; Zhu Hang; Liu Mai-Li | |
刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
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2008-07-01 | |
卷号 | 36期号:7页码:935-940 |
关键词 | nuclear magnetic resonance diffusion-weighted nuclear magnetic resonce (NMR) coronary heart disease principal component analysis |
英文摘要 | It is demonstrated that combination of diffusion-weighted NMR spectroscopy and principle components analysis (PCA) can be used to discriminate serums of patients with coronary heart disease (CHD) from that of health subjects. Diffusion-weighted H-1 NMR spectroscopy is a powerful approach for enhancing resonances from large molecules and suppressing resonances of low molecular-weight metabolites without disturbing physiological properties of human serum samples. The best diffusion weighting factor is found to be around b = 0.85 x 10(7) s/cm(2), increasing or decreasing the diffusion weighting factor destructs the discrimination efficiency. These preliminary results show that high density and low density lipoproteins (HDL & LDL) are the key components contributed to the discrimination, while very small metabolites (such as lactate etc.) and larger lipoproteins (such as very lower density lipoproteins, very low density lipoproteins (VLDL etc. have less effects. |
WOS标题词 | Science & Technology ; Physical Sciences |
类目[WOS] | Chemistry, Analytical |
研究领域[WOS] | Chemistry |
关键词[WOS] | PRINCIPAL COMPONENT ANALYSIS ; HUMAN BLOOD-PLASMA ; NMR-SPECTROSCOPY ; LIPOPROTEINS ; COEFFICIENTS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000258939700014 |
公开日期 | 2015-10-13 |
内容类型 | 期刊论文 |
源URL | [http://ir.wipm.ac.cn/handle/112942/8079] ![]() |
专题 | 武汉物理与数学研究所_2011年以前论文发表(包括2011年) |
作者单位 | Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
推荐引用方式 GB/T 7714 | Lan Wen-Xian,Zhu Hang,Liu Mai-Li. Separating human serums of health and hyperlipidaemia subjects using diffusion-weighted nuclear magnetic resonance spectroscopy[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2008,36(7):935-940. |
APA | Lan Wen-Xian,Zhu Hang,&Liu Mai-Li.(2008).Separating human serums of health and hyperlipidaemia subjects using diffusion-weighted nuclear magnetic resonance spectroscopy.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,36(7),935-940. |
MLA | Lan Wen-Xian,et al."Separating human serums of health and hyperlipidaemia subjects using diffusion-weighted nuclear magnetic resonance spectroscopy".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 36.7(2008):935-940. |
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