Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 2011年以前论文发表（包括2011年）

	Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels
	Yin, Shi-Jin 1; Jiang, Ling 2; Yi, Hong 1; Han, Song 1; Yang, Dai-Wen 3; Liu, Mai-Li 2; Liu, Hui 1; Cao, Zhi-Jian 1; Wu, Ying-Liang 1; Li, Wen-Xin 1
刊名	JOURNAL OF PROTEOME RESEARCH
	2008-11-01
卷号	7 期号:11 页码:4890-4897
关键词	Kv1.1 channel Kv1.3 channel channel turret ADWX-1 peptide selectivity structural basis
英文摘要	The low selectivity of Kv1 peptide inhibitors for specific isoforms makes them poor candidates for the development of theraputics. Using combined approaches, we showed that the Kv1 turret is the critical determinant for ADWX-1 peptide inhibitor selectivity of Kv1.3 over Kv1.1. Mutation of Kv1.1 turret residues to match the sequence of Kv1.3 lead to increased inhibition of Kv1.1 activity. These studies may lead to improvements in peptide inhibitor drug development.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Biochemical Research Methods
研究领域[WOS]	Biochemistry & Molecular Biology
关键词[WOS]	MEMORY T-CELLS ; INDUCED CONFORMATIONAL-CHANGES ; TORSION ANGLE DYNAMICS ; DEPENDENT K+ CHANNEL ; POTASSIUM CHANNELS ; AUTOIMMUNE-DISEASES ; THERAPEUTIC TARGET ; SCORPION TOXINS ; MOLECULAR-BASIS ; MUTANT CYCLES
收录类别	SCI
语种	英语
WOS记录号	WOS:000260792000028
公开日期	2015-10-13
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/8055]
专题	武汉物理与数学研究所_2011年以前论文发表（包括2011年）
作者单位	1.Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 3.Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore
推荐引用方式 GB/T 7714	Yin, Shi-Jin,Jiang, Ling,Yi, Hong,et al. Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels[J]. JOURNAL OF PROTEOME RESEARCH,2008,7(11):4890-4897.
APA	Yin, Shi-Jin.,Jiang, Ling.,Yi, Hong.,Han, Song.,Yang, Dai-Wen.,...&Li, Wen-Xin.(2008).Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels.JOURNAL OF PROTEOME RESEARCH,7(11),4890-4897.
MLA	Yin, Shi-Jin,et al."Different Residues in Channel Turret Determining the Selectivity of ADWX-1 Inhibitor Peptide between Kv1.1 and Kv1.3 Channels".JOURNAL OF PROTEOME RESEARCH 7.11(2008):4890-4897.