Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat | |
Luo Jia1,2; Wang Tao1; Liang Shan1,2; Hu Xu1; Li Wei1,2; Jin Feng1 | |
刊名 | SCIENCE CHINA-LIFE SCIENCES |
2014-03-01 | |
卷号 | 57期号:3页码:327-335 |
关键词 | hyperammonemia probiotics cognition anxiety neuroinflammation serotonin |
ISSN号 | 1674-7305 |
英文摘要 | Evidence suggests that the hyperammonemia (HA)-induced neuroinflammation and alterations in the serotonin (5-HT) system may contribute to cognitive decline and anxiety disorder during hepatic encephalopathy (HE). Probiotics that maintain immune system homeostasis and regulate the 5-HT system may be potential treatment for HA-mediated neurological disorders in HE. In this study, we tested the efficacy of probiotic Lactobacillus helveticus strain NS8 in preventing cognitive decline and anxiety-like behavior in HA rats. Chronic HA was induced by intraperitoneal injection of ammonium acetate for four weeks in male Sprague-Dawley rats. HA rats were then given Lactobacillus helveticus strain NS8 (10(9) CFU mL(-1)) in drinking water as a daily supplementation. The Morris water maze task assessed cognitive function, and the elevated plus maze test evaluated anxiety-like behavior. Neuroinflammation was assessed by measuring the inflammatory markers: inducible nitric oxide synthase, prostaglandin E2, and interleukin-1 beta in the brain. 5-HT system activity was evaluated by measuring 5-HT and its metabolite, 5-HIAA, and the 5-HT precursor, tryptophan. Probiotic treatment of HA rats significantly reduced the level of inflammatory markers, decreased 5-HT metabolism, restored cognitive function and improved anxiety-like behavior. These results indicate that probiotic L. helveticus strain NS8 is beneficial for the treatment of cognitive decline and anxiety-like behavior in HA rats. |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000332740100007 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/14129] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Luo Jia,Wang Tao,Liang Shan,et al. Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat[J]. SCIENCE CHINA-LIFE SCIENCES,2014,57(3):327-335. |
APA | Luo Jia,Wang Tao,Liang Shan,Hu Xu,Li Wei,&Jin Feng.(2014).Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat.SCIENCE CHINA-LIFE SCIENCES,57(3),327-335. |
MLA | Luo Jia,et al."Ingestion of Lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat".SCIENCE CHINA-LIFE SCIENCES 57.3(2014):327-335. |
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