Genetic linkage analysis in the age of whole-genome sequencing

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	Genetic linkage analysis in the age of whole-genome sequencing
	Ott, Jurg 1,2; Wang, Jing1 ; Leal, Suzanne M.3
刊名	NATURE REVIEWS GENETICS
	2015-05-01
卷号	16 期号:5 页码:275-284
ISSN号	1471-0056
英文摘要	For many years, linkage analysis was the primary tool used for the genetic mapping of Mendelian and complex traits with familial aggregation. Linkage analysis was largely supplanted by the wide adoption of genome-wide association studies (GWASs). However, with the recent increased use of whole-genome sequencing (WGS), linkage analysis is again emerging as an important and powerful analysis method for the identification of genes involved in disease aetiology, often in conjunction with WGS filtering approaches. Here, we review the principles of linkage analysis and provide practical guidelines for carrying out linkage studies using WGS data.
收录类别	SCI
语种	英语
WOS记录号	WOS:000353164800009
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/13523]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA 3.Baylor Coll Med, Dept Human & Mol Genet, Ctr Stat Genet, Houston, TX 77030 USA
推荐引用方式 GB/T 7714	Ott, Jurg,Wang, Jing,Leal, Suzanne M.. Genetic linkage analysis in the age of whole-genome sequencing[J]. NATURE REVIEWS GENETICS,2015,16(5):275-284.
APA	Ott, Jurg,Wang, Jing,&Leal, Suzanne M..(2015).Genetic linkage analysis in the age of whole-genome sequencing.NATURE REVIEWS GENETICS,16(5),275-284.
MLA	Ott, Jurg,et al."Genetic linkage analysis in the age of whole-genome sequencing".NATURE REVIEWS GENETICS 16.5(2015):275-284.