Tamoxifen effects on the early life stages and reproduction of Japanese medaka (Oryzias latipes)

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	Tamoxifen effects on the early life stages and reproduction of Japanese medaka (Oryzias latipes)
	Sun, Liwei ; Zha, Jinmiao ; Spear, Philip A. ; Wang, Zijian
刊名	ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
	2007-07
卷号	24 期号:1 页码:23-29
关键词	tamoxifen selective estrogen-receptor modulator (SERM) early life stage reproduction transgenerational effects
英文摘要	Tamoxifen is widely used in the treatment of breast cancer and can enter the aquatic environment in municipal wastewater. To evaluate potential effects on embryonic development of Japanese medaka, fertilized eggs were exposed to tamoxifen at 1-625 mu g/l for 14 days. Adverse effects on hatchability and time to hatching only occurred at 125 and 625 mu g/l. Reproductive effects were assessed by exposing adults for 21 days to the same dose range. At all concentrations tested, tamoxifen significantly increased plasma vitellogenin levels in males in a dose-dependent manner. Fecundity and fertility were detrimentally affected at 625 mu g/l. Additionally, F1 eggs were removed from tamoxifen-contaminated water to evaluate transgenerational effects. Hatchability was affected at 625 mu g/l but no morphological deformities were observed. A significant dose-dependent increase in the proportion of genotypic males occurred at all concentrations greater than 5 mu g/l. (C) 2007 Elsevier B.V. All rights reserved.
WOS记录号	WOS:000246837100005
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/22601]
专题	生态环境研究中心_环境水质学国家重点实验室
推荐引用方式 GB/T 7714	Sun, Liwei,Zha, Jinmiao,Spear, Philip A.,et al. Tamoxifen effects on the early life stages and reproduction of Japanese medaka (Oryzias latipes)[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2007,24(1):23-29.
APA	Sun, Liwei,Zha, Jinmiao,Spear, Philip A.,&Wang, Zijian.(2007).Tamoxifen effects on the early life stages and reproduction of Japanese medaka (Oryzias latipes).ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,24(1),23-29.
MLA	Sun, Liwei,et al."Tamoxifen effects on the early life stages and reproduction of Japanese medaka (Oryzias latipes)".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 24.1(2007):23-29.