Novel Single Nucleotide Polymorphisms of the Insulin-Like Growth Factor-I Gene and Their Associations with Growth Traits in Common Carp (Cyprinus carpio L.)

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	Novel Single Nucleotide Polymorphisms of the Insulin-Like Growth Factor-I Gene and Their Associations with Growth Traits in Common Carp (Cyprinus carpio L.)
	Feng, Xiu 1,2; Yu, Xiaomu 1; Tong, Jingou 1
刊名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
	2014-12-01
卷号	15 期号:12 页码:22471-22482
关键词	common carp IGF-I SNP growth trait association study
ISSN号	1422-0067
通讯作者	Tong, JG (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
英文摘要	Insulin-like growth factor-I (IGF-I) plays an important role in the growth and development of vertebrates. To study polymorphisms of IGF-I, we screened a total of 4555 bp of genomic sequences in four exons and partial introns for the discovery of single nucleotide polymorphism (SNP) in common carp (Cyprinus carpio). Three SNPs (g. 3759T> G, g. 7627T> A and g. 7722T> C) in intron 2 and a nonsynonymous SNP (g. 7892C> T) in exon 3 were identified in a pilot population including random parents and their progenies. 289 progenies were further genotyped for studying possible associations between genotypes or combined genotypes and growth traits. The results showed that the locus g. 7627T> A was significantly associated with body weight and body length, and fish with genotype AA had a mean body weight 5.9% higher than those with genotype TT. No significant associations were observed between genotypes of other loci and growth traits. However, when both g. 7627T> A and g. 7722T> C were considered, the combined genotype TT/TT was extremely associated with the lowest values of body length and body weight and the highest K value in comparison with other diplotypes (p < 0.01). These results suggest that genotype AA at g. 7627T> A and its combined genotypes with alleles from another locus have positive effects on growth traits, which would be a candidate molecular marker for further studies in marker-assisted selection in common carp.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
研究领域[WOS]	Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]	IGF-I ; 5'-FLANKING REGION ; ATLANTIC SALMON ; CANDIDATE GENES ; HORMONE GENE ; SEQUENCE ; WEIGHT ; CATTLE ; POPULATION ; EFFICIENCY
收录类别	SCI
语种	英语
WOS记录号	WOS:000346797400054
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/23922]
专题	水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文
作者单位	1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Feng, Xiu,Yu, Xiaomu,Tong, Jingou. Novel Single Nucleotide Polymorphisms of the Insulin-Like Growth Factor-I Gene and Their Associations with Growth Traits in Common Carp (Cyprinus carpio L.)[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2014,15(12):22471-22482.
APA	Feng, Xiu,Yu, Xiaomu,&Tong, Jingou.(2014).Novel Single Nucleotide Polymorphisms of the Insulin-Like Growth Factor-I Gene and Their Associations with Growth Traits in Common Carp (Cyprinus carpio L.).INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,15(12),22471-22482.
MLA	Feng, Xiu,et al."Novel Single Nucleotide Polymorphisms of the Insulin-Like Growth Factor-I Gene and Their Associations with Growth Traits in Common Carp (Cyprinus carpio L.)".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 15.12(2014):22471-22482.