Characterizations of four toll-like receptor 4s in grass carp Ctenopharyngodon idellus and their response to grass carp reovirus infection and lipopolysaccharide stimulation

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	Characterizations of four toll-like receptor 4s in grass carp Ctenopharyngodon idellus and their response to grass carp reovirus infection and lipopolysaccharide stimulation
	Pei, Y. Y.1,2; Huang, R.1; Li, Y. M.1; Liao, L. J.1; Zhu, Z. Y.1; Wang, Y. P.1
刊名	JOURNAL OF FISH BIOLOGY
	2015-03-01
卷号	86 期号:3 页码:1098-1108
关键词	gene expression grass carp reovirus subcellular localization tissue distribution virus infection
ISSN号	0022-1112
通讯作者	Wang, YP (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.
英文摘要	In this study, the subcellular localization, tissue distribution and response to grass carp reovirus (GCRV) infection and lipopolysaccharide (LPS) stimulation of four grass carp Ctenopharyngodon idellus toll-like receptor 4 (tlr4) genes were investigated. All four genes were constitutively expressed in all tissues studied, but the subcellular localization and tissue exhibiting the highest expression differed for each protein. Following GCRV infection, all the four tlr4s were upregulated in all tissues examined, and stimulation of C. idellus kidney (CIK) cells with LPS resulted in downregulation of all four tlr4s. These results provide a foundation for further investigation of tlr4 genes in bony fishes. (C) 2015 The Fisheries Society of the British Isles
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Fisheries ; Marine & Freshwater Biology
研究领域[WOS]	Fisheries ; Marine & Freshwater Biology
关键词[WOS]	CATFISH ICTALURUS-PUNCTATUS ; RESPIRATORY SYNCYTIAL VIRUS ; GENE FAMILY ; PATHOGEN RECOGNITION ; CHANNEL CATFISH ; INNATE IMMUNITY ; TLR4 GENE ; SIGNAL-TRANSDUCTION ; EXPRESSION ANALYSIS ; PATHWAY
收录类别	SCI
语种	英语
WOS记录号	WOS:000351356700013
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/23901]
专题	水生生物研究所_鱼类生物学及渔业生物技术研究中心_期刊论文
作者单位	1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Pei, Y. Y.,Huang, R.,Li, Y. M.,et al. Characterizations of four toll-like receptor 4s in grass carp Ctenopharyngodon idellus and their response to grass carp reovirus infection and lipopolysaccharide stimulation[J]. JOURNAL OF FISH BIOLOGY,2015,86(3):1098-1108.
APA	Pei, Y. Y.,Huang, R.,Li, Y. M.,Liao, L. J.,Zhu, Z. Y.,&Wang, Y. P..(2015).Characterizations of four toll-like receptor 4s in grass carp Ctenopharyngodon idellus and their response to grass carp reovirus infection and lipopolysaccharide stimulation.JOURNAL OF FISH BIOLOGY,86(3),1098-1108.
MLA	Pei, Y. Y.,et al."Characterizations of four toll-like receptor 4s in grass carp Ctenopharyngodon idellus and their response to grass carp reovirus infection and lipopolysaccharide stimulation".JOURNAL OF FISH BIOLOGY 86.3(2015):1098-1108.